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NAS Does Not Appear to Consider Bias or Conflicts of Interests in Picking Panels -Report

Discussion in 'Institute of Medicine (IOM) Government Contract' started by justinreilly, Nov 21, 2013.

  1. justinreilly

    justinreilly Stop the IoM & P2P! Adopt CCC!

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    Center for Science in the Public Interest report blasts National Academies of Science committees as laden with undisclosed bias and conflicts of interest. The Institute of Medicine is one of the National Academies of Sciences ("NAS")

    "Ensuring Independence and Objectivity at the National Academies" 2006

    [All Bolding is from the original; underlining and italics added for emphasis]

    Thanks to Leela for finding this!

    http://cspinet.org/new/pdf/nasreport.pdf

    taniaaust1, aimossy, Izola and 2 others like this.
  2. Ren

    Ren One of nineteen million dark horses.

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    Thanx, Leela and J.Reilly!
    Izola likes this.
  3. jspotila

    jspotila Senior Member

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    Has anyone reached out to CSPI to see if they have updated the analysis since 2006. If they still feel there is a problem, that would be VERY helpful to know.
    Izola likes this.
  4. justinreilly

    justinreilly Stop the IoM & P2P! Adopt CCC!

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    That could be helpful. I would suspect there is no change. I am too busy right now. Do you mind contacting them if this is important to you?
  5. jspotila

    jspotila Senior Member

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    Can't. Dealing with two huge CFSAC issues, at least one of which will break this week. Plus gearing up for IOM panelist research.

    Anyone else have a few minutes to devote to checking this out?
  6. Ren

    Ren One of nineteen million dark horses.

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    A general search does not reveal anything new - though I could have of course missed something.

    Contact Info:

    Center for Science in the Public Interest
    1220 L St. N.W.
    Suite 300
    Washington, D.C. 20005
    Main switchboard: (202) 332-9110
    Fax: (202) 265-4954
    cspinews@cspinet.org

    The listed email info is for journalists and questions re articles (see original website for more info). The following was sent today, but who knows if they'll reply re this matter:

    "Hi - In 2006, your organization released the report, "Ensuring Independence and Objectivity at the National Academies" (http://cspinet.org/new/pdf/nasreport.pdf). Can you tell me, please, if CSPI has evaluated the National Acadamies, particularly the Institute of Medicine since this 2006 report?

    And could you additionally please say if CSPI would be interested in evaluating the upcoming committee selection for IOM's controversial and much-protested redefinition of myalgic encephalomyelitis (WHO G93.3)? Thank you..."
  7. alex3619

    alex3619 Senior Member

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    :thumbsup:
    justinreilly, Ren and aimossy like this.
  8. justinreilly

    justinreilly Stop the IoM & P2P! Adopt CCC!

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    Hey, if anybody comes across any reading material about 'this is how you make a case definition' can you please post it here? Thanks.
  9. alex3619

    alex3619 Senior Member

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    For outbreaks the CDC advises the following for case definitions: http://emergency.cdc.gov/urdo/pdf/CaseDefinitions.pdf

    This will give some insight into what should have happened at Incline Village etc. Its not very useful for the IOM issue though.

    Here is something for animals, which is more thorough than the CDC is for humans:

    http://www.fao.org/docrep/007/y5325e/y5325e0c.htm

    I would suggest that a case definition is not what we are looking for. The use of the word "case" will lead to identification of specific cases in specific outbreaks, and is not about general diagnostic definitions. However there is also the issue that diagnostic definitions may bias any search toward testing.

    This one is more relevant as it looks at panels, diagnostic definitions and industry bias:
    http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001500

    This last one includes comments like this: "No publication included rigorous assessment of potential harms of proposed changes."

    In relation to biomarkers there is this attempt at a qualitative approach:
    jrheum.com/omeract/download.php?username=omeract&pdf=8-607

    I don't think this is an http address, enter it into the browser and refresh and it will download the document.

    For a biased discussion of biomarkers, and a new term "information based medicine" here is an IBM document: http://www-935.ibm.com/services/us/gbs/bus/pdf/g510-6640-00_biomarker.pdf

    This appears aimed at a more bioinformatics approach.
    Last edited: Nov 27, 2013
    justinreilly likes this.
  10. justinreilly

    justinreilly Stop the IoM & P2P! Adopt CCC!

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    Man, these guys love the 'diversity/outside-opinion' thing. I saw this on wikipedia:

    "An unusual diversity of talent among Institute members is assured by the charter stipulation that at least one-quarter be selected from outside the health professions, from such fields as the natural, social, and behavioral sciences, as well as law, administration, engineering, and the humanities."
  11. alex3619

    alex3619 Senior Member

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    IOM standards emphasize stakeholders including patients be included in their panels. That is another failure for the IOM.
  12. Ren

    Ren One of nineteen million dark horses.

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    @alex3619 - I'm very nearly all read-out today, but since you mentioned "biomarkers" above - I wanted to mention that I earlier noticed the following 2010 IOM text: Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease. http://www.nap.edu/openbook.php?record_id=12869

    As I said, I happened upon it in some earlier reading material. (At that time, I did a quick search for "fatigue", "myalgic" and "virus" - but had zero hits. I was of course looking for as related to: chronic fatigue syndrome, myalgic encephalomyelitis, or post-viral fatigue syndrome.)

    Just thought I'd mention the text though, should it be something you believe could somehow be useful. :)
    Last edited: Dec 15, 2013
  13. alex3619

    alex3619 Senior Member

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    @Ren, thanks. I am looking at it, but it has to be loaded page by page, you can't download without a password. It appears mostly to be about the FDA using biomarkers to monitor drugs.
    Ren likes this.
  14. Ren

    Ren One of nineteen million dark horses.

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    @alex3619, Thank you for looking further into the above report, especially since it seems to be a dead end. (Odd re the password request. I didn't experience that - go figure.) Thanx again. :)

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