@Dufresne , yea I do experience both improved PEM and mental clearing together, but I haven't watched it close enough to say whether one is more pronounced than the other on day one vs day two. @Wayne .... I would be interested to know how you felt after taking a few Ty3's a day for a few days. See if you get this same kind of response. For myself, even though these drugs work so well, I must find an alternative to narcotics.