As it relates to Marco’s thinking on the subject, as well as taking something I knew to be risky for me, I thought I’d post a little about my experimentation with GBL and Baclofen. With GBL I had no excitotoxicity. I also couldn't trigger PEM no matter how much I read, whereas a long paragraph used to cause me problems. Neuro-symptoms disappeared, and I enjoyed an increased tolerance for exercise. GBL is a potent GABA-B agonist but it stimulates the hell out of endorphins too. You do develop a bit of tolerance to it within a week of regular dosing which leads to a slight rebound for a day or two, though hardly a remarkable worsening of excitotoxicity which is what I was expecting. Of course if one were taking it around the clock for an extended period of time I imagine the withdrawal would be similar to that of alcohol. I started taking Baclofen, hopefully a sustainable GABA-B receptor agonist, and the results have been promising. I can get 80 mg/day prescribed here legally. Some of that wired feeling is dissipating. I should add that I’m not endorsing GBL use or even Baclofen therapy, and I’ll have anybody reading know that I”m not combining these two. Just thought the effects might be of interest to certain posters on this thread.