1. Patients launch a $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
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Lessons from ME/CFS: Finding Meaning in the Suffering
If you're aware of my previous articles here at Phoenix Rising then it's pretty clear that I don't generally spend my time musing upon the philosophy of the disease. I find it better to spend my time reading research and trying my best to break it down to its core elements and write...
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Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination

Discussion in 'Other Health News and Research' started by Ecoclimber, Jun 11, 2014.

  1. Ecoclimber

    Ecoclimber Senior Member

    Mercer Island Wa
    Lancet Neurol. 2014 Jun;13(6):600-613. doi: 10.1016/S1474-4422(14)70075-4.
    Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination.
    Partinen M1, Kornum BR2, Plazzi G3, Jennum P4, Julkunen I5, Vaarala O6.
    Author information


    Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin) neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at onset is 12-16 years. Narcolepsy is strongly associated with the HLA-DQB1*06:02 genotype, and has been thought of as an immune-mediated disease. Other risk genes, such as T-cell-receptor α chain and purinergic receptor subtype 2Y11, are also implicated. Interest in narcolepsy has increased since the epidemiological observations that H1N1 infection and vaccination are potential triggering factors, and an increase in the incidence of narcolepsy after the pandemic AS03 adjuvanted H1N1 vaccination in 2010 from Sweden and Finland supports the immune-mediated pathogenesis. Epidemiological observations from studies in China also suggest a role for H1N1 virus infections as a trigger for narcolepsy. Although the pathological mechanisms are unknown, an H1N1 virus-derived antigen might be the trigger.

    A follow-up on my post here:
    Are vaccines the cause of ME/CFS?

    Last edited: Jun 11, 2014
    merylg, natasa778, Bob and 1 other person like this.

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