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Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination

Discussion in 'Other Health News and Research' started by Ecoclimber, Jun 11, 2014.

  1. Ecoclimber

    Ecoclimber Senior Member

    Mercer Island Wa
    Lancet Neurol. 2014 Jun;13(6):600-613. doi: 10.1016/S1474-4422(14)70075-4.
    Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination.
    Partinen M1, Kornum BR2, Plazzi G3, Jennum P4, Julkunen I5, Vaarala O6.
    Author information


    Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin) neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at onset is 12-16 years. Narcolepsy is strongly associated with the HLA-DQB1*06:02 genotype, and has been thought of as an immune-mediated disease. Other risk genes, such as T-cell-receptor α chain and purinergic receptor subtype 2Y11, are also implicated. Interest in narcolepsy has increased since the epidemiological observations that H1N1 infection and vaccination are potential triggering factors, and an increase in the incidence of narcolepsy after the pandemic AS03 adjuvanted H1N1 vaccination in 2010 from Sweden and Finland supports the immune-mediated pathogenesis. Epidemiological observations from studies in China also suggest a role for H1N1 virus infections as a trigger for narcolepsy. Although the pathological mechanisms are unknown, an H1N1 virus-derived antigen might be the trigger.

    A follow-up on my post here:
    Are vaccines the cause of ME/CFS?

    Last edited: Jun 11, 2014
    merylg, natasa778, Bob and 1 other person like this.
  2. Gemini

    Gemini Senior Member

    Key Narcolepsy-Influenza Vaccine Findings Retracted, Stanford researchers unable to replicate findings linking immune response to sleep disorder. Science, 1 August 2014, page 498.

    "Emmanuel Mignot of Stanford University in Palo Alto, California, and colleagues retracted their influential study reporting a potential link between the H1N1 virus used to make the vaccine [Pandemrix] and narcolepsy."

    "The retraction states that Mignot and his colleagues were unable to replicate the results of the ELISpot assay, a widely used method for measuring how the immune system cells such as T cells respond to fragments of foreign proteins, called antigens. Mignot told Science that while attempting to develop a diagnostic test for narcolepsy based on the assay, my lab could not make the ELISpot test work."

    Had Mignot's results held, they could have led to the first proven example of a vaccine triggering an autoimmune response by mimicking the body's own proteins...."
    Last edited: Aug 15, 2014

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