Naphazoline is an alpha 2 adrenergic agonist which is used as a common decongestant. I have had some positive experience with it. It seems to reduce the feeling of the "swelling of the brain". I have three possible explanations for this: 1. It is a potent vasoconstrictor drug, which can reduce a swelling of brain blood vessels (by the way about 50% of known brain diseases are related to dysfunctional brain vascular systems) 2. It can, even if only weakly, cross the blood brain barriers and interfere with adrenergic receptors in the brain or if applied intranasally it can directly migrate into the brain through the cribriform plate. 3. Some other physiological effects of naphazoline are involved. Be careful with experimenting with this (mainly) OTC drug. Signs of naphazoline poisoning are pallor, hypertension, bradycardia and in severe cases pulmonary edema.