Discussion in 'Latest ME/CFS Research' started by Kati, May 25, 2010.
4 potential bio-markers|!!??!! Pinch me. I must be dreaming.
The closing slide of Nancy Klimas' presentation at the IiME conference listed the following biomarkers for, and mediators in, ME. Please do not ask me to explain them.
Perforin as a surrogate for NK cells, also measures cytotoxic T cell function
NPY (and directly impacted by CD26)
Cytokine multiplex methods
Panels pointing to pro-inflammatory cytokine elevations, TH2 cytokine elevations, etc.
I have more notes but it will take a while to compile them.
OK, so this is awesome, and Nancy one of my favorite super sexy fierce heroes, but...what now?
She had a small study of 176 patients and 230 controls. It was funded by the CAA, NIAA (National Institute on Alcohol Abuse and Alcoholism), NHLBI (National Heart, Lung and Blood Institute), and NIAID. She's following up with a longitudinal study with about the same # of people.
It was be my life's dream and frankly tear inducing if one could walk into a PCP office, get some blood requisition, and get a diagnosis. No schlepping around to specialist, no one accusing patients of depression or failing at life.
For something to be a standard test it has to be 1) replicated 2) repeated and found true on a HUGE number of people and not in controls and then FDA approved, insurance-covered, and hopefully put in the Merck Manual, etc. (And sanctiond by the NYSDOH which apparently doesn't allow NCK function testing.)
What can we do to help this happen?
I'm with you, Robin. I keep seeing studies come out but no one doing the follow-up to make a diagnostic test that is "FDA approved, insurance-covered, and hopefully put in the Merck Manual, etc."
I have no idea what patients can do to push the work needed to create a standardized diagnostic test but I agree with you that it is sorely needed.
Hi, Im currently in a cfs study here in australia, they are studying the function of natural killer cells, not just numbers, anyway after the first round of blood tests they have found cfs pts compared to the healthy controls have poor natural killer cell function, so another study validating our problems with our immune system. They also said that because of this that we can then be prone to other infections. I was once told by a docotor that ebv reactivation only occurrs in aids and cancer patients going through chemo, these sort of studies are proving that cfs patients could have ebv reactivation as well as other infections that are thought of as benign such as mycoplasma etc
Heapsreal~ Is anything published yet in the study that you are participating in?
Rock on: another paper to put in the hands of uninformed and/or incurious docs.
hi timaca, nothing yet, the study is over an 18month period with blood tests done every 6 months, so i assume at the end of the 18month period, so another 12 months to go.
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