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NAD, Niacinamide and methylation

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by PeterPositive, Sep 23, 2014.

  1. PeterPositive

    PeterPositive Senior Member

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    Hi,
    I have recently experimented adding 25mg of NAD in sublingual form (this product) and I've found that it provides a nice energy boost without increasing anxiety, which is good :)

    I am considering taking this every day and maybe taking it even twice a day if I find myself running out of juice, so to speak.

    Question is... will NAD interfere with the methylation supplements? Niacin/Niacinamide is known to be a sponge for methyl groups and it's used to counteract the side effects of methyl-folate & C... I have no idea if NAD has the same properties and what would be a safe dose of NAD to avoid slowing down my already sluggish methylation?

    thanks
     
  2. adreno

    adreno PR activist

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    I think you will be fine. You still need some B3 one way or the other, and if you like the active form then 25mg isn't a huge dose anyway. It's true that B3 mops up excess methyl groups, but it also has many other functions.
     
  3. PeterPositive

    PeterPositive Senior Member

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    Thanks.
    I noticed that niacin and niacinamide supplements come usually in much higher doses, such as 250mg, 500mg and more. Is there any equivalence between say 500mg of niacinamide and X mg of NAD? Or it just doens't make sense?

    I suppose it's not an easy question :)
     
  4. sregan

    sregan Senior Member

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    NAD is a more active form of B3 and I would assume you need Less of it. As p5p is the most active form of B6 I might take 10mg sublingual instead of a 50mg b6.


    NADH is even more active (but way more $$$) and something you might consider trying. However, if you do good on NAD you're lucky! I've got a bottle of NAD (and just about everything else) and it's not been any better than Niacin as far as I can tell.
     
    PeterPositive likes this.
  5. adreno

    adreno PR activist

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    Yeah, it's probably about 5x stronger than regular B3.
     
  6. Sherpa

    Sherpa Ex-workaholic adrenaline junkie

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    Had good luck, also, with NADH. Lots of energy, not too much anxiety.
     
  7. Critterina

    Critterina Senior Member

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    Don't NAD and NADH push one reaction different ways, so that if what you're trying to do is get it to go one way, taking the other is counterproductive? (I did that by taking DMG when I needed TMG and that was not good!) Can anyone point me to that chemical equation?

    I've also had good results from NADH, but it is pricey! So a less expensive alternative would be good, unless I'm doing myself in with it.
     
  8. Gloria H

    Gloria H

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    I'm wondering how niacinamide compares to NAD in bio-availability etc. I want B3 but I have no need to dampen methylation.
     
  9. Jarod

    Jarod Senior Member

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    planet earth
    I take numerous b vitamins. I take all the b vitamins seperately to identify what works and what doesn't.

    Niacin and B1 are a couple of my favorite b vitamins. Can't function without them, as I start getting gum problems.

    B6 makes me severly agitated if I get too much. In fact, I just avoid it completely. In fact It is possible to overdose on B6 pretty easily for me. This has been tested in blood.
     
    Last edited: Sep 25, 2014
  10. PollyH

    PollyH

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    Niacinamide mops up methyl groups when the body converts it to NAD. So, if you are low in methyl groups, it would be better to try NAD from products like Niacel, Niagen, and Coenzymated B3.

    I prefer NAD to NADH. (In cases of yeast overgrowth and alcoholism, there is too much NADH compared to NAD.) They have been using IV NAD (Niagen) to treat alcoholism. They have discovered that there is a point at which you can get too much NAD. The NAD will convert into NADH and other products, and this will block some of the properties of NAD. There is more information about this at the website for NAD intravenous treatments in San Diego.

    PS: I could not tolerate niacinamide or B6, but I am fine with P5P and NAD.
     
  11. AnkeC

    AnkeC

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    Since my lactate/pyruvate ratio is out of whack I thought I would give Niagen a go.
    Oh boy.
    Today is only day 1.......and I took 100mg on an empty stomach, instead of the recommended 250mg. And I have been sick as a dog all day. No idea if it's a clue, but I got the same heady nausea symptoms I get from most pain killers...... (as well as diarrhoea). I realise of course that it takes a lot longer to work out if a supplement does what it is touted to do.....but I can't function with my head like this, so it's a bust for me I'm afraid. :(
     
  12. Gondwanaland

    Gondwanaland Senior Member

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    For high lactate I would try B1 first, not without cofactors (B2, B6, magnesium, potassium, etc)
     
    AnkeC likes this.
  13. AnkeC

    AnkeC

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    It’s not the lactate that’s high, it’s the pyruvate.

    I already do activated b’s, monthly magnesium injections, etc
     
    Gondwanaland likes this.
  14. nanonug

    nanonug Senior Member

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    Do you know what your pyruvate/citrate ratio is?
     
    AnkeC likes this.
  15. AnkeC

    AnkeC

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    Citrate? uhm. No. I only have Lactate and pyruvate.
    Assuming I did the maths right, and there is a good chance I didn’t, I thought L : P is 10 But having just checked my unit conversion, I think it’s more like 100, which would be normal.
    (Isn’t it odd to express a ratio with a single number?)

    However using the formula specific to elevated pyruvate (from another thread quoting http://www.lunaliving.org/pdf/nad_therapy_e-book.pdf). The value is 63.
    Which denotes an energy block ....somewhere....because of .....something. (You can tell how scientificy I am). My pyruvate level is 120 umol/L or 0.12 mmol/L

     
    Last edited: Mar 17, 2018
    BadBadBear likes this.
  16. nanonug

    nanonug Senior Member

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