Hello everyone . Methylation has done wonders for me, even though I can only tolerate tiny amounts of B12. I am now about to start an antibiotic protocol (cefuroxime and doxycycline for 2 months) to treat a Yersinia infection. I read about taking NAC to limit damage to mitochondria from antibiotics, and that sounded like a good idea. But today I found an old thread here that says NAC can mess up methylation. What's the latest word on that? Should I be concerned? I tried 600mg NAC for the first time yesterday (no antibiotics yet). It had a stimulant effect for a few hours and then a bit of a crash when it wore off. Maybe a mild histamine effect, too. Does this tell y'all anything? Methylations supps do decrease my pain level a lot, and histamine increases it. And what else should I take to help me deal with the antibiotics when I start them? Lots of vit C? Anything else? Thanks for any help .