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n-acetylcysteine (NAC) (N-A-C)

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by soccer_dude, Aug 23, 2016.

  1. soccer_dude

    soccer_dude

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    Hi,

    I've read that NAC can reduce glutamate levels or block their receptors and is a supplement that could help with insomnia. So, I added a small dose of NAC, about a half of a capsule which I'm assuming is about 200-250mg before bed along with my other supplements. This seemed to help. But after a couple of weeks my insomnia is worse.

    The last couple of days I tried a full capsule of NAC 500mg in the morning on a empty stomach. It seemed to brighten my mood and mental energy, but later in the day I started feeling very ill. I slept worse, and so I thought I'd try it again this morning to see if it is indeed the NAC, and I believe so as I'm still feeling ill. Not sure why I didn't feel ill taking smaller doses at night before bed, but now I'm just feeling terrible.

    Anyone else with this experience? I feel okay taking Glutathione and have been taking that on/off for a while.

    I'm not sure if this is a detox reaction because I've been taking other detox products for some time and shouldn't have such a reaction taking NAC, but you never know. But I have read that nausea and vomiting, etc... are all possible side-effects of NAC. I haven't read too many reviews of this being the case but....

    I'm also CBS ++ although my urine sulfate levels are someone in a good range, and my ammonia levels tested fine. I don't think CBS is the reason NAC is making me feel worse. I can take Taurine and Glutathione and feel fine.

    I'm going to go off NAC for a few days (or indefinately) and see if I feel better.

    Cheers!
     
    aaron_c likes this.
  2. Valentijn

    Valentijn The Diabolic Logic

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    I take 600mg of sustained release NAC three times per day, and do good on it. I have trouble sleeping if it wears off. Normal NAC wears off very quickly (within a couple hours), which is why sustained release might work better.

    The CBS SNPs have pretty much no effect at all. So I'd agree that they aren't relevant to your reaction :D
     
    Sing likes this.
  3. Cheesus

    Cheesus Senior Member

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    NAC caused me an absolutely brutal crash. I mean seriously, seriously brutal. I took two 600mg capsules over the course of two days and by the end of the second day I was in an ME horror story where I stayed for nearly 6 weeks. I am confident that if I had kept taking it I would have died. Not exaggerating.
     
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  4. Cheesus

    Cheesus Senior Member

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    I should also add that NAC is a T-cell agonist, so if whatever subset you and I belong to is caused by T-cell hyperactivity, then you have your answer.

    How long have you been ill for?
     
  5. Sing

    Sing Senior Member

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    NAC sustained release of at least 600 mg at bed or earlier in the evening does help me with both pain and sleep. If I take 1200 mg, however, the next morning my blood pressure is lower than ever so I don't take that amount. The NAC I do take, by itself, would not deal with my sleep issues but it makes a helpful contribution.
     
    Wayne and Valentijn like this.
  6. soccer_dude

    soccer_dude

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    Hi,

    I went off NAC and started feeling better but my insomnia never improved. I tried a little NAC at bed time again but didn't help. I tried it the other day and I believe it caused next day nausea all day again.

    Not sure why it helped for a few weeks and now I just feel worse when taking it.

    Could it be causing some sort of methylation blockage? Cysteine combines with glycine and glutamine to make glutathione. I some times take glycine but not so much glutamine, could there be some issue with lowered glutamine levels? I'm reaching a bit here but.....

    I liked how it helped with my brain health and sleep but not the nausea effect. I will be talking to my ND about this next visit. She suggested stopping NAC for now.

    Interesting stuff.
     
  7. Paintmyturquoise

    Paintmyturquoise

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    I'd suggest that your body has reduced glutathione/NAC levels for a reason. Thus increasing it makes your underlying issue/infection/etc worse

    Nausea was a problem for me early in this severe crash. It gradually went away. Presumably my body adapted these hormones/proteins/processes so whatever was happening stopped happening?
     
    Star-Anise likes this.
  8. Paintmyturquoise

    Paintmyturquoise

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    Also this
     
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  9. Valentijn

    Valentijn The Diabolic Logic

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    This isn't how glutathione works. Various enzymes connect it to specific problematic substances, such as toxins, and remove them. There's no indication that glutathione can ever cause damage or feed infections.
     
    arewenearlythereyet, Sing and Helen like this.
  10. Helen

    Helen Senior Member

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    I agree, on the contrary as far as I know. One of my doctors told that the reduced glutathione rather is a consequence of my infections as they increase the need for glutathione.
     
  11. soccer_dude

    soccer_dude

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    I'm still off NAC for now. I do try a half a capsule every now and then at night to see if it helps with sleep or if it makes me feel worse. Jury is out still on if it's helping or not. I'm wondering if NAC did cause some excess mercury detox and I didn't have enough binders to bind and remove it from my body. I am taking more chorella and cilantro, etc... which should help bind and remove heavy metals. I haven't been tested has having high mercury levels. I did have two pin dot size fillings at one time, but they've been removed. HOWEVER, I did play with mercury in my hand as a kid one time before I knew any better so that would be the largest exposure I would have had to mercury. Yikes I know!
     
  12. Sing

    Sing Senior Member

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    @soccer_dude

    Since you mentioned that you take chorella too, I remembered all the stomach cramping and nausea I had from the only time I tried that. Never again! Upon looking up its side effects today, I see those are common side effects. This may not pertain to you, but I mention it for other people here.
     
  13. soccer_dude

    soccer_dude

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    I definately had some nausea from taking Chlorella in the past. Currently I've been using Source Naturals "Cilantro Metal Detox" which contains Cilantro and Chlorella in a liquid form. There's only 250mg of Chlorella per serving. I was only occasionally using it but have started using it more frequently without any noticable nausea. I have even taken it on an empty stomach without any noticable nausea. It may not be real potent but I can at least tolerate using it.
     
    Last edited: Nov 7, 2016
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  14. Jenny TipsforME

    Jenny TipsforME Senior Member

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    Just saw this on an Amazon review

    Is this person right and at what point of stinkiness would you know NAC has lost its efficacy? :thumbdown: eg @Valentijn do you know? Other online comments seem to think that the smell is part of nature of the product.

    Also somewhere on PR there's someone who had amazing benefits from NAC for a while then no benefit. Could it be the NAC going off rather than their body?

    I'm taking NAC irregularly to induce sleepiness and avoid tired but wired state and also for congestion (so my supply is liable to go off and does have an eggy smell).
     
    Last edited: Dec 22, 2016
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  15. Valentijn

    Valentijn The Diabolic Logic

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    Mine's always a bit stinky, and I'm quite sure that it's been effective regardless. I notice pretty soon if I miss a dose, since I get wired-but-tired and have trouble sleeping - I've never had that happen when taking a dose, regardless of the smell.

    I think the reviewer has their head up their bum. Some brands simply mask smells more than others. It happens a lot with fish oil as well, where thyme or lemon are used to make it smell fresher and less fishy.

    In the case of Swanson, it probably doesn't smell much because it's encased in a gelatin capsule, whereas other brands (definitely Jarrow) are a tablet. If the Swanson capsule was opened, I imagine it would have the same smell.

    I also don't see any support for the reviewer's claim that NAC degrades into anything problematic.
     
    Last edited: Dec 22, 2016
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  16. aaron_c

    aaron_c Senior Member

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    I'm having this problem too--at first NAC helped with sleep, but now it seems to increase insomnia. I tried taking glycine, but that doesn't seem to have helped. I'm fairly sure it's not mobilizing mercury since I went through 3.5 years of chelation therapy to get rid of the mercury.
     
  17. aaron_c

    aaron_c Senior Member

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    From a 1985 study: The mucolytic drug N-acetyl cysteine has been shown to release histamine from cultured mouse mast cells and from human basophils.

    Don't know why this would take a week or two to show up, though. Maybe when it was fixing more of an acute deficiency the NAC was getting sucked up more quickly, so there was less floating around to trigger mast cells and/or basophils? Maybe when it gives you insomnia that means you don't need to take that much?

    Maybe taking NAC that is not "extended release" spikes NAC too much, which causes the mast cells and basophils to release histamine?

    They also mention that the more acidic the NAC-rich medium, the more histamine got released. Maybe that's part of it?

    I'll try taking more stuff that inhibits mast cell degranulation and see if that helps.
     
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  18. Valentijn

    Valentijn The Diabolic Logic

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    No idea regarding histamine, but non-extended release would wear off after 3-4 hours. So it might be harder to sleep after that happens :p
     
    aaron_c likes this.
  19. antherder

    antherder a.k.a. Princess Dauer, Nematode Nation

    I have seen suggestions that NAC chelates copper, but don't know if there's any science to back that up.
     
    aaron_c likes this.
  20. Star-Anise

    Star-Anise Senior Member

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    I recently decided to try NAC at the advice of my naturopath as a beginning place to start to restore my liver function. I have no liver function formal tests, but I am pretty sure that I have weak Phase 2 detox. I have trouble with sulfite metabolism & my endocrine function is impaired. I also just get a bloated, blocked, awful feeling when I try to induce Phase 1.

    I did not use extended release, and used a very tiny dose (like 1/64 tsp of inside of a 500mg pill) & I found it to be very very stimulating. Thankfully I just used a bit, but it was rage-like, irritability. It felt "glutamate-y" - if that makes sense. I know that my neurotransmitter activity is very very sensitive. Due to NAC's influence on glutamate, I wonder if it is just as simple as rocking a very, very sensitized boat in my brain - even if it was a good thing, the ride is just too rocky for me.

    I've also been reading about underlying Mercury toxicity (I had amalgam fillings for years). Could this be the issue even at such a low, low dose?

    Thanks for any info that anyone can provide. This is my next learning curve.
     

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