Someone asked, so here they are, with my commentary HOMOZYGOUS: VDR Taq (rs731236) MTRR A66G (rs1801394) CBS A360A (rs1801181) HETEROZYGOUS: COMT V158M (rs4680) COMT H62H (rs4633) MTHFR 03 P39P (rs2066470) MTHFR A1298C (rs1801131) AHCY 01 (rs819147) AHCY 02 (rs819134) AHCY 19 (rs819171) So I might be a bit low on vitamin D 25 due to the VDR Taq. According to heartfixer, this can cause low dopamine. My dopamine tests pretty normal, though somewhat closer to the low end. MTRR A66G affects homocysteine (higher) and methionine (lower) levels a bit, which might explain mildly elevated homecysteine levels I had a while ago. Results from last year also show homocysteine on the high end of normal and methionine on the low end of normal. So nothing dramatic going on, but I might benefit from getting things closer to the middle of the range. CBS A360A is meaningless, so I can ignore that one. According to heartfixer (someone should probably tell them that the 10x up-regulation is horribly wrong - a rather embarrassing mistake to be promoting) it's an upregulation. But my levels of things shown as coming "after" the CBS enzyme are low or normal, not high. Heterozygous COMT's aren't really a risk. At most it means I'm not breaking down catecholamines particularly quickly or slowly. The AHCY SNPs listed are meaningless. MTHFR A1298C without MTHFR C677T shouldn't have much impact on folate levels, if any. Heartfixer says it might cause low BH4. Low BH4 can cause low catecholamines, which might be about half true in my case: low norepinephrine and serotonin, but normal dopamine and high-normal epinephrine. Phenylalanine, which BH4 processes into catecholamines, is normal, not high at all, so that doesn't seem to support the theory of low BH4. Other substances which BH4 breaks down, tyrosine and tryptophan, are quite low for me, barely in the reference range. So if MTHFR A1298C does have an impact on BH4, I'd be surprised if the heterozygous version is at all revelant. MTHFR 03 P39P does seem to have some sort of effect in a couple studies, but the heterozygous version doesn't make it to a statistically significant level. It's also not clear what the effect actually is.