Hello everyone. I'm not really sure if I have CFS or it is just a depression something else. I hope you guys can give me some hints according to my symptoms and reactions to supplements. It all started when I was around 18 (now 30) with a mild depression and then all the other symptoms began. Symptoms: sudden overwhelming sleepiness at some point after noon (mostly after work and not related to meals) forcing me to take a nap (eyes closing on their own) - every other day, especially on weekends when I slept longer than 8 hours sudden tiredness making me yawn, that can last for hours and is sometimes followed by sleepiness tiredness (yawning) starting during exercise - occurs sometimes after a high intensity workout (resistance training or running) mostly I feel really good but it is sometimes followed by really bad sleep, heavy night sweating, high heart rate, high body temperature, the next day massive brain fog and tiredness - happens mostly when I already feel tired after a workday - lasts only a day not feeling fully rested after sleep - 99% of all nights since 12 years regularly waking up at night at almost exactly 4 am – mostly during times of higher stress often lack of concentration due to mild brain fog often low motivation often lowered mood and kind of depression - through the years I had some moderate depressive episodes alcohol hangovers can lower my mood and energy sometimes for days and weeks and sometimes just only for some hours sometimes anxiety difficulty finding words (getting worse) lowered libido other physical conditions: - eczema around the anus since 8 years. during the years had it also on other body parts but it disappeared on its own - white tongue, although I clean it every morning and evening (happens ultra-fast when I drink beer), can't remember when it started - mucous in the throat after the night (mostly green, not always) - maybe since ten years Although my symptoms maybe sound quite severe, most of the time I’m feeling fine. the biggest impairment for me is the lack of motivation and the low mood, which changes unexplainably form day to day. Of course the tiredness, but it's only a big deal at work or after work. I tried some supplements during the years. I will just mention those which had the biggest effect (pos and neg) gaba -> could not sleep all night long, never tried it again tyrosin -> somehow enhanced my motivation ashwagandha -> wow, makes me feel super calm (take it almost daily) cholin -> depressive symptoms MethylB12 (without folate) -> lowered mood arginine + ornithine -> depression omega 3 -> midly improves my mood urdine + dha -> really boosted my motivation myo-inositol -> really anxiolytic even at small doses – suddenly stopped working phosphatidylserine -> wow, high motivation, energy and enhanced cognitive function – discontinued it because I thought it would reinforce the “next day crashes” after workouts ...and at the end the best thing: methylfolat 800mcg (started it with hydroxylB12, although I have no B12 deficiency) After the first day I took it, ALL my symptoms where gone (but it just lasted 2-3 days). Since then the improvements are at least by 50%, which is also great. I take it since about a month and since a week I trying it with MethylB12 (although nutrahacker says I should avoid methyldonors). I think it improved my concentration even more, but the methylb12 changes my personality somehow and I have a strange mood (sometimes good sometimes bad). Ashwagandha doesn’t seem to work anymore since I introduced MethylB12. I also don't experience the neurological brightening with methylB12, people talking about (tried up to 2mg under the lip). Below I attached are my methylation related snps and my nutrahacker report. Despite MTHFR 1298C homo, I don’t see any rare (and well reasearched) mutations. I hope maybe someone sees a pattern here or at least give me hint what to look for. Thanks for your comments.