My success story. Tons of biotin. Hi. I am a male from Russia, 26 years old. My weight is 65 kg and my height is 178 cm. I have had deadly hard symptoms, all in my brain: extreme fatigue, feeling of stupidity in the head, feeling of emptiness or pressure in the head, bad sleep. And I was feeling improvements for short periods of time after each carbohydrate meal. I was unable to sleep without eating in the night. Year after year, there was more consumption of carbohydrates needed to maintain the same level of energy, and bearable time after each meal was also becoming shorter and shorter. So I also started to move towards obesity. It was so hard that I was really planning on suicide. But I thought it worth trying to spend rest of my money on experiments with some organic substances. So after a while I had found the solution! My regimen: For day: Biotin 10,000 mcg (I am using this one), get the powder from the capsule and put it under the tongue, repeat it every 30-40 minutes (it have little effect or no effect if is eaten - it is necessary to have biotin under the tongue almost all of the time, and to have it wet). If I feel not enough saliva in the mouth (or not enough effect), I add 1 sublingual tablet of "5000 mcg Biotin" (this one - it was designed to be dissolved under the tongue, so it dissolves faster). For meal time (all under the tongue): 1 capsule of "10,000 mcg Biotin" (powder) in the middle of mealtime. Can be repeated if the meal time lasts long. Before sleep (all under the tongue): 4 sublingual tablets of "5 mg Melatonin" (probably not necessary, but I love it, and it also helps to moisten biotin powder with saliva), then 4 capsules of "10,000 mcg Biotin" (powder), then let it dissolve a bit for a few minutes, then again take 4 capsules of "10,000 mcg Biotin" (powder), and then 4 sublingual tablets of "5000 Biotin". I call it "the sandwich of tablets". It works well for a few hours, but not for entire sleep. When I waking up in the night (all under the tongue): 1 capsule of "10,000 mcg Biotin" (powder), then 4 sublingual tablets of "5000 Biotin" (yes, make the sandwich again). Can be repeated if necessary. Usually I need this step for 2-6 times before wake time (I sleep about 9-10 hours). Side effects of such large doses of biotin (all are solved): Stomach problems. Heartburn (usually after bath and sometimes in morning). How I treat stomach problems: Special diet: 3 glasses of warm water before each meal, 700-800 gramms of raw bananas (measured with peels) and 3 egg whites (from 65-74,9 gramm eggs) each meal (3 time a day). Sometimes I also eat a yolk (usually 1-3 yolks a week). Between meals, if I feel acidity in stomach - 1 glass of warm water and 1 or 2 bananas. After each meal or snack I take 5 capsules of "400 mg Slippery Elm" (swallow without water). If I feel acidity during sleep - 5-15 capsules of "400 mg Slippery Elm" (while lying on the bed, swallow the capsules without water). It worth mentioning that I also consume multivitamins and fish oil capsules, so my diet is not as monotonous as it can appear. And I avoid physical activity because it can give me stomach pain. How I treat heartburn: 1 glass of warm water and 1 banana, then 15 capsules of "400 mg Slippery Elm" (swallow without water). Sometimes I feel no symptoms, sometimes I feel near to that - it's very good regimen for me. I started it few years ago and nothing wrong with my liver. I believe I have some very rare and unknown metabolic genetic disease. If you have similar symptoms and my solution helps you - please let me know.