Hi Everyone, Firstly I’d like to thank each and every poster here for posting their experiences. This collective knowledge is invaluable. Like many here I have had many years of baffling ill health. I have been though Candida diets, Adrenal/Endocrine support and Mercury Chelation amongst other things. About two months ago my research lead me to pyroluria, this was purely based on many matching symptoms. With extra B6/P-5P and zinc (along with EPO and Manganese) I got a noticeable lift in energy and a slight improvement in mood. This encouraged me to research further which brought me to Methylation and this forum. About 6 weeks ago I took a B Complex capsule that contained roughly 200ug of 5-Methyltetrahydrofolate. The results were dramatic. I had dragged myself through that day with next to no energy and this one capsule felt like 6 cups of coffee (but with only a fraction of the jitters associated with high coffee consumption). Being worried about such an extreme reaction, I proceeded more cautiously after that, starting at 50ug and increasing by about 50ug per day. In the process I got some of the well-known start up reactions. I had one day of extreme depression (I have suffered from mild to moderate depression for many years but this was much worse), I then has a day where it felt that my neck was in a vice. This was resolved by drastically increasing my potassium. I increased magnesium too (all this based on advice thanks to this forum). All ok so far, but this is when it got a bit strange. It all stopped working. Looking at my records I have now got up to 3.2mg of Metafolin, 3-4mg of Mb12, 1mg of Adb12 and 850mg of LCF. And nothing - little energy, low mood, low motivation and drive. Basically pretty much how I felt before I started the methylation supplements. I stopped taking my multivitamin (Thorne Research, Citrate Formula, Basic Nutrients III Without Copper and Iron) sue to its Folinic Acid content. Then a few days later I re-read my B Complex formula (Country Life, Gluten Free, Coenzyme B-Complex Caps) only to find it contained Folic Acid! What I find a little strange is that this is the very same B Complex that gave me massive energy initially. I have stopped both the multi and B Complex for 6 days now. I seem to recall a note from Freddd stating that Folic Acid blocks Folate for 5-7 days (Folinic Acid for longer). I expect in the near future that my methylation will increase as the Folic Acid (and perhaps Folinic Acid) drops out my system. What I need to know is when this does happen will my current level of supplementation cause massive over-methylation? The level I am currently taking is about 10 times more than when it last worked for me. Any comments or thoughts would be greatly appreciated. Many Thanks.