Hi all! @caledonia, I've been using your documents as a guide to getting started with SNPs and methylation treatment. If you can, I'd love your guidance here! Anyone else's guidance is also appreciated!!!! @Freddd I need some help with B12 and I haven't come across people with my experience so far in the forum despite lots of searching. I've had years of poor health including severe autoimmune, digestive problems, hormonal abnormalities, neurological problems, and fatigue/weakness etc to the point of being bedridden, on and off, for months on end. Despite trying a lot of different things, nothing has shown continued response like adeno B12 (perhaps hydroxy too, I don't know if my positive response is continued yet). These issues began after taking a prescription drug and have been with me for over a decade. I'm really trying to address the autoimmune and digestive problems before neurological, or all 3 at the same time. My B12 experience with different forms of B12 on their own: -Cynocobalamin doesn't do anything. -Mb12 causes severe, debilitating headaches and a general feeling of fatigue and being unwell. -Adeno, which I began using 4 months ago, caused the neurological brightening effect that Freddd talks about from Mb12 plus more energy. -Hydroxy, which I began this week taking orally with food (not sublingually), gives me more energy and mental focus and let's me multitask again, improves digestion, but makes it hard to sleep. Combinations: If I take adeno first I can tolerate methyl, but it still causes some headache/slowdown. Ratio 3000 mcg adeno / 250 mcg methyl. More: I had been taking Freddd's recommended cofactors, but stopped most because of digestive problems. I think the B12 needs to be in place for digestion before they can benefit me. Except 2: Vitamin C, I feel horrible when I take it, and don't plan to start again, and I may start low dose MTHFL again despite no mutations on the MTHFR gene. Yasko's B12 guidance suggests Hydroxy and Adeno. So given this guidance and that both of these forms seem to work for me over methyl, I'm pursuing these first. My questions are: -How much and at what ratio of Hydroxy and Adeno B12 are people having luck with when supplementing? -Since people take shots of Hydroxy, is it safe to take larger amounts orally from the beginning? -Does anyone have guidance or experience to share?