It's funny that you call me brave because I remember about two years ago, answering a poll on Rituximab here on PR. It was asking whether if the possibility existed, would've agree to try Rituximab. I had answered- no. The reason being that I was so sick and was afraid to take the chance of exacerbating my condition. I had read some first hand accounts if ME patients trying it and feeling really worse. I just couldn't phantom that. Now two years later, things have changed for me. Because of my diagnosis of RA and an pretty aggresive course, I have a different evaluation now. So far other RA meds have not reversed, nor stopped the progression. I am facing a real possibility of becoming somewhat crippled and eventually affecting other body parts. In face if this possibility, my view for myself has changed. In addition, I gave since heard of many who either had slight side effects or none. I have heard of ME patients for whom Rituximab is helping quiet impressively. Thank you for calling me brave though. I enjoyed that !