I have received the results for MTFHR. They do not seem too bad, but I just started delving into the science. Of particular interest, I found: - MTHFR A1298C: BH4 acts as a rate limiting factor for the production of neurotransmitters and catecholamines including serotonin, melatonin, dopamine, norepinephrine, and epinephrine. A MTHFR A1298C + status may cause a decrease in any of these neurotransmitters or catecholamines. BH4 is also a cofactor in the production of nitric oxide. A dysfunctional BH4 enzyme may lead to mental/emotional and/or physical symptoms. Mercury, lead, and aluminum may act as a drain on BH4. (Comment) I am depressed, have low serotonine and horrible sleep issues. However, I think my (nor)epinepherine might actually be too high because I have symptoms of POTS. - CBS A360A: It has also been observed that BH4 can also become depleted with a CBS upregulation. BH4 helps regulate neurotransmitters and mood (Comment) Note the mention of mood again. It seems like both mutations are dropping the BH4 levels. This is my limited reading so far. Can someone shed more lights on the results? I might be very wrong in saying "not too bad".