(I guess this could fall into the alternative therapies-cathegory, but since it's also about immune modulation I post it here. Move it if you want to.) First: Did anyone else here have adverse effects from goji berries? 1-2 hour after taking a handful I start feeling really bad with CFS symptoms which I associate with the immune system: Sore armpits, sore throat, hot face, feeling feverish and like there is an elephant balancing on my chest. These symptoms go away (or return to their "normal" level, rather) after 3-4 hours. (The first time I thought it must be a coincidence. So, being a dedicated empiricist, I tried again. And again. After four times, different days, with exactly the same results I was both convinced and fed up with feeling bad so I gave them to a non PWME-friend who ate them gladly and without any problems.) I've been thinking back and forth about what might have happened and found these two facts: First: A study on mice says that mice fed with goji berries "showed overall, significantly higher concanavalin A-induced IL-2 production (P < 0.05)." http://www.ncbi.nlm.nih.gov/pubmed/22739381 Second: IL-2 is (according to Dr Google) a "potent activator for B-cells and NK-cells." And of course I jumped when reading B-cells, thinking of the rituximab trials. My two questions: 1. Did anyone else have the same or a different reaction to goji berries? 2. Is it possible that my reaction was caused by IL-2 activating B-cells? Considering the time frame that process must be quite quick for that theory to hold up. What say you? Any immune experts out there? If this proved to be correct and a certain percentage of PWME:s react the same way I did then that might give us some clues to what the role of the B-cells are in ME/CFS and why rituximab helps.