New step in my Lyme journey : I switched yesterday from mynocycline to a new tetracycline after my doc's supervision, this one is called Tetralysal in Europe (Lymecycline). This drug brought me the baddiest Herx I've had so far... With half a doze only... I thought the antimalarial RIAMET showed me what an Herx could be, I had an additionnal lesson. Last night I experimented : - repetitive dyspnea from 23.00 to 3.00 - heartburn so bad I could hardly move my diaphragme + belching (never have) - temperature fell down and I was frozen - vivid nightmares with moments of total confusion, didn't know if I was awake or not. Though I tried to interrupt them several times by waking-up, moving to an other room etc. they went back to square 1 as soon as I went back to sleep. - rushing brain with "hearing" unwanted mantra "cat's claw without TOA" in a loop, driving me crazy - bad nocturia from 23.00 to 5.00 (once every hour) (the same day, I just wrote on PR that this awful symptom went away with minocycline) - increased high pitched tinnitus - feeling poisoned - extra systoles I woke-up this morning, after two hours of uninterrupted sleep, feeling like after an hang-over. I was scared to renew the experiment today, as brain symptoms were so frightening . Surfing on a French Lyme forum (where some folks were taking tetralysal), I hoped to have some indication. And in the mid-time, I made a coffe enema to see if it could bring some improvement. The result was better that I imagined,and I could be functionnal in some way after that. Even, feeling more energetic than usual... Returning to the computer, I was answered that what I went through last night was a typical post-tetralysal Herx, and I would have to work more on the detox. (And don't hesitate to stop for two days if this was hardly bearable and resume ABX after pause). I thought I knew what Herxing may be. I didn't. And I am quite sure those nasty bugs keep some additionnal surprises for their host . Why have 2 tetracycline (first, Minocycline, then Tetralysal) caused so diffrent reactions? Mino was a "picnic". Perhaps I have some clue here : 1. I took mino alone, it was like an "introduction". It is a bacteriostactic, and in quantitiy has bactericid action. It seems it didn't reach this point. 2. Right after the 6 weeks of mino, I took the RIAMET for Babesia (high doses pulsed on 4 days). One of the two ingredients stays inside the body from 2 (control) to 6 days (Bab. people) after stopping the drug. 3 When I began Tetralysal, I was on day 3 of ceasing the riamet, so there is chance the antimalarial was still in the body, and coupled with the new tetracycline, it made a powerful cocktail (like anti protozoaire+ tetracycline). And the bactericid action was powerful, drawing some hard herx.