I don't have gut issues like some here. In spite of losing my colon, it really doesn't bother me much. No pain or inflammatory problems. My difficulties are all related to function - I have food sensitivities (improving except for gluten which is worse. I think the colon was a buffer) and I have problems absorbing some stuff. Mostly I have no clue about what I do and do not absorb. But B2 (see A B2 Story) and methylfolate are ongoing reproducable problems for me. I have tried to take mfolate capsules and nothing - I took 5 x 1000 mcg yesterday for example and I am still trying to recover. I only need about 1500 mcg a day when it's left in the buccal pouch every 3 hours (or more often if brain-fog increases). I don't need support. I can't take probiotics - that does give me pain. What I want to tell people is that some may have a problem with absorption as well and to suggest that s.l. might be helpful. I notice a decrease in fog within minutes.