Things have really started to spiral down again for me since upping the Methylfolate. I have been on 10mg+ last couple of days. While it initially seemed to get me better, I've experienced intense stomach pains in my lower abdomen, bloating, gas and general IBS from hell. Good thing is the shortness of breath seems to be almost gone. Could be attributed to higher Potassium intake. Tingling/burning has come back a bit as well as what feels like cramp in my muscles/nerves which makes it hard to grip things for a short moment, general stiffness of muscles. Concentration/short term memory has been taking a hit as well. Damn you body! why you so complex Anyways, been doing some research and thinking that I probably should sort out some things first (dont know if anyone agrees with me here): Yasko mentions to deal with the Gut and Glutamate/GABA balance before starting methylation. For the latter, apparently the GAD1 gene is implicated in this process of regulation and have role of converting Glutamate to GABA. Ran my genetics data and found out that I had defects (heterozygous) in nearly ALL the GAD1 genes, one being homozygous. According to theory, this could very well explain some things about my anxiety which just been growing and growing the last couple of years. My diet also consists of pretty high glutamate food which is something I didn't really know until now. Thing is, I tried Tianeptine (new type of antidepressant) for a month which really calmed me down, worked incredible well. One of its mechanism is to help balance Glutamate/GABA as well as protecting the NMDA receptors where it partially works as an antagonist. Unfortunately I ran out (pretty expensive) and then started methylation as I got my genetics result. So right now, I'm thinking about trying to balance the Glutamate/GABA as well as focus on Gut health. I've had increasing problems with my Gut over the last couple of years which I really havnt payed attention to, stupid I know. Probably gonna talk to my doc about this. As for the methylation-protocol, I'll probably continue but maybe will lower the dose(s) a bit and see how things progress. I still feel positives like energy levels which has been a huge lift for me.