I just want to mention very briefly my experience which may highlight something we have never considered before. For a long time I've had issues with mild fungal overgrowth in my gut (as many of us have). This has never resolved despite very low carbohydrates for 2 years and anti-fungals etc. My symptoms are only mild - lots of gas issues after ingesting sugar. Very repeatable experience. I've been positive for fungal overgrowth in previous tests (and negative for SIBO). Recently I washed my sinuses daily with the anti-fungal amphotericin-b (follwing the "Brewer" protocol loosely). The only change I noticed after 3 weeks of this was that I no longer have that gut issue, which raises the interesting possibility that the fungal overgrowth is caused my a connection between the nasal passages/sinuses and the gut. This would explain why people very often find almost no solution when treating the gut.