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My homozygous MTHFR SNPS:

Discussion in 'Genetic Testing and SNPs' started by Methyl Health, Nov 10, 2014.

  1. Methyl Health

    Methyl Health

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    These are my homozygous MTHFR SNPS:
    MTHFR A1298C rs1801131 G GG +/+
    MTHFR rs1476413 T TT +/+
    MTHFR rs3737964 T TT +/+
    MTHFR rs4846048 G GG +/+
    MTHFR rs4846049 T TT +/+

    I definitely see how this SNP effects me now. It seems I can lower my systolic blood pressure (This mornings reading went from 141 to 112) by taking riboflavin-5′-phosphate (FMN) and 3MG of 5-MTHF. I am going to do some more testing by just taking the Riboflavin but I wonder if we could talk about this. The 5-MTHF supplements are so much more expensive, I was thinking of going up to 5MG 5-MTHF and it will cost me about $30 per month. So with that price difference in mind I was wondering if I even need to take it if FMN can do it on its own.

    I am having a hard time understanding the role and relationship of NADP+, NADPH, FAD, and FMN with MTHFR. It seems like NADPH is also a cofactor. Do I need to take Nicotinamide as well? Ugh.

    I am wondering to if my lower blood pressure has more to do with how FMN affects Nitric Oxide coupling.

    NOTE
    : I do not worry about my diastolic BP, it seems it is irrelevant and that we should only focus on the systolic as a marker for health and hypertension.
     
  2. Critterina

    Critterina Senior Member

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    Arizona, USA
    Methylfolate, almost certainly. Have you ever had neurotransmitter issues? (anxiety, depression, bipolar, OCD, autism spectrum, ADHD, wired/tired feeling, mood swings, migraines?) Those are all associated with MTHFR A1298C rs1801131 G GG +/+. So, methylfolate would be important unless all of those sound unfamiliar to your experience.

    You might try Piping Rock for your methylfolate. They seem to have the least expensive Metafolin(R) brand methylfolate I've found.
     
  3. liverock

    liverock Senior Member

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    UK
    Methyl Health likes this.
  4. Critterina

    Critterina Senior Member

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    Arizona, USA
    Methylfolate is available in the US by prescription at 7.5 and 15 mg. If you do well on 5 mg and have health insurance, you might ask your doctor about Deplin.
     
  5. PennyIA

    PennyIA Senior Member

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    My regular doc is with yours. I do see a methylation specialist via skype and telephone calls and he could prescribe the rx, but truly I'm mostly up to 15 mg per day now (though I have had periods where I needed a break and had to build back up)... so I buy it without an rx.
     
  6. CFS_for_19_years

    CFS_for_19_years Hoarder of biscuits

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    Just a thought to keep in mind: Diastolic BP represents the baseline BP that your system experiences at all times and if it is too high, lets say, 90, there can be long-term consequences (heart disease, kidney disease, etc.)

    http://blood-pressure.emedtv.com/diastolic-blood-pressure/diastolic-blood-pressure-p2.html

    Even if you could get your doctor to give you a prescription, there's no guarantee your insurance will cover it as it is classified as "medical food." Good for you if you can get it covered by insurance though.
     
  7. Helen

    Helen Senior Member

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    A high homocysteine and/or low folate. There are lots of articles and studies of the enzyme activity and mutations in MTHFR A1298T that should convince your doctor.
     

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