These are my homozygous MTHFR SNPS: MTHFR A1298C rs1801131 G GG +/+ MTHFR rs1476413 T TT +/+ MTHFR rs3737964 T TT +/+ MTHFR rs4846048 G GG +/+ MTHFR rs4846049 T TT +/+ I definitely see how this SNP effects me now. It seems I can lower my systolic blood pressure (This mornings reading went from 141 to 112) by taking riboflavin-5′-phosphate (FMN) and 3MG of 5-MTHF. I am going to do some more testing by just taking the Riboflavin but I wonder if we could talk about this. The 5-MTHF supplements are so much more expensive, I was thinking of going up to 5MG 5-MTHF and it will cost me about $30 per month. So with that price difference in mind I was wondering if I even need to take it if FMN can do it on its own. I am having a hard time understanding the role and relationship of NADP+, NADPH, FAD, and FMN with MTHFR. It seems like NADPH is also a cofactor. Do I need to take Nicotinamide as well? Ugh. I am wondering to if my lower blood pressure has more to do with how FMN affects Nitric Oxide coupling. NOTE: I do not worry about my diastolic BP, it seems it is irrelevant and that we should only focus on the systolic as a marker for health and hypertension.