First, hello all... my first post here, though I've read a lot. Super short version for me: I was diagnosed with MTHFR C667T about 8 years ago when pregnant with my 4th baby (was tested due to pre-eclampsia history). At the time I was told no hormonal birth control, to take aspirin for life and I was put on injectable blood thinners for pregnancy baby #4 and #5. Fast forward to the last 2 years or so. My health has declined tremendously to the point of chronic pain, chronic fatigue, multiple joint dysfunction, etc (lots more, but for brevity's sake...) Before losing health insurance, I had a partial work-up with my GP and a full work up with a neurologist (one working diagnosis was MS, which did not pan out). Neurology work up was negative except for severe bilateral CTS. I lost my insurance before I was able to get in with the rheumatologist (neuro suspected lupus, though my tests were always negative). Soooo, I started doing some research on my own and was surprised to see that my MTHFR mutation could be attributed to MANY of the symptoms I had been experiencing. I undertook an attempt at methylation on my own (I know, I know) about 2 months ago and its been a mixed bag, but mostly negative. Suspecting there was more to the picture (you think?!), I did the 23andme test and lo and behold, I have multiple SNPs. The more I read, the more confused I become. What is clear to me at the moment (I think) is that I need to address my CBS mutation first, so stopping my methylation protocol, and then go from there. Then I read elsewhere that one of my detox mutations makes it less likely that some standard CBS protocols will work for me. And apparently some mutations cancel out other ones??? Please help me make sense out of this. Help me find a plan so that I can feel hopeful that I can do something. My homozygous mutations: VDR Taq MAO A R297R MTHFR C677T MTRR A664A CBS A360A My heterozygous mutations: COMT V158M COMT H62H MTR A2756G MTRR A66G BHMT-08 SHMT1 C1420T On the MTHFR.net detox profile my homozygous: Detox: NAT2 T341C (I114T), SOD2, SOD2 A16V IgE: CD14 Clotting factors: F11 (so I have Factor XI deficiency, right?) Methylation: AGT M235T/C4072T, CBS A360A, DAO (GG), All 3 FUT2 (what is this?), MAO A R297R, MTHFR C677T, MTHFS, MTRR-11 A664A, MTRR, SLC19A1 x 2, TYMS Mitochondrial: NDUFS7 x 4, NDUFS8 Those are just the homozygous, I have a BUNCH of hetero ones, too. I can share those, but I am overwhelmed with just these!