Hi all, I am hoping someone can help with interpreting my results. I have done my own research but I am honestly swamped with information. I can research each SNP no problem, but when they start having synergistic effects on each other I get confused. From my results I understand my COMT Mutations will cause me to no break down neurotransmitters (which makes sense because I am an insomniac (my brain is always buzzing, cant relax). How can I resolve this? My COMT and VDR taq = "It has been clinically observed that the body may have trouble tolerating methyl donors with a COMT V158M + and a VDR Taq + status" Ok. So how do I tackle this? Supplementing with hydroxocobalamin instead of methyl? I also have Gut issues (as per my other thread), so if you think any of these are related please let me know. (sulphur/ammonia?) Sorry for the noob post, but I am struggling. I'd really appreciate some help.