I started taking Fludrocortisone last year and it has been really helpful for my POTS symptoms. No brain fog anymore. Feeling alive and engaging in normal life. However after about 4 months, I began to have anxiety issues and be oversensitive for almost no reason. I began taking antidepressants (Serpass, Anafranil) and (Zoloft, Lexatonil) in low doses to cover the symptoms and it helped. After about 5 months I began to be overwhelmed about the amount of medication I take a day and began to recognize that my problem could be due to low levels of potassium in my body. I decided to stop the medication and see if my POTS symptoms would come back. To my surprise, I felt almost normal for two months. Oh my God! I didn't believe that just happened. So I discontinued psychiatric drugs gradually and kept taking Serpass only. The third months, I began having some symptoms again which increased gradually. So I would take 0.1 or 0.2 dose a day for a couple of days till my symptoms go away then stop it again. And that is how I managed the third month after discontinuation. In the forth month, I found that a dose for two days was not really helping! So I took it for a little longer hoping it would alleviate my symptoms, but it didn't. So I overdosed until I got better. I began to feel good but anxiety struck again so I decided I would keep taking the medicine while taking potassium supplement (2500 mg a day) to help my anxiety symptoms go away. My POTS symptoms struck again and that time it refused to improve. I discontinued potassium (I had doubt it could be contributing to fludrocortisone being less effective) and kept taking fludrocortisone in 0.4 mg a day (a large dose I know but I was hopeless). Can (taking Potassium tablets along with fludrocortisone) or(overdosing on fludrocortisone like 0.4 mg per day) cause the medication to be less effective?