I think is very counteractive for ME to provoke that state, it will only crash you and suffer for no reason. Start slow and titrate, if you are getting that bad means you went too fast up. My CFS Dr always says only increase when there are no side effects, if you do have side effects stay in current dose or go back to the one without symptoms. I started 1/2 pill (250mg) once a day for 2 weeks, then 1/2 2 times a day for 2 weeks, then 1/2 3 times a day for 2 weeks, then the 2 pills a day. Best of luck.