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My Dopamine Concern: DBH, GCH1 and COMT

Discussion in 'Genetic Testing and SNPs' started by TheChosenOne, Sep 6, 2015.

  1. TheChosenOne

    TheChosenOne Senior Member

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    What really works for me is lithium, magnesium, phosphatidylcholine, tyrosine and a B complex.
    Magnesium and lithium increase COMT expression. Phosphatidylcholine helps BHMT, but more importantly, it saves some SAMe. SAMe is needed for COMT to work. Phosphatidylcholine is also very beneficial for my sister, so there must be some genetic benefit.
    I've run my 23andme file through MTHFRSupport and I was scrolling through it, when I came across an area with a lot of red SNPs in the 'Neurotransmitter Pathway'. I don't think I have a serotonin problem, but I do have a dopamine problem.
    The SNPs that you were talking about (++, +- and -- are copied from MTHFRSupport):
    MAOB
    rs2283729
    G
    rs1799836
    C -
    MAO.png
    DDC (This is both AAAD and 5HTD in the pathways below, helping create serotonin and dopamine as well.)
    rs3735273
    CC ++
    rs1451375
    CC --
    rs921451
    TT ++
    rs2329340
    CC
    rs1451371
    CT +-
    DDC.png
    DBH
    rs77905
    AA ++
    rs1108580
    GG --
    rs2007153
    CC ++
    DBH.png
    TPH2
    rs4570625
    GG
    rs17110690
    GG
    rs4565946
    CT
    rs10506645
    CC
    rs1487278
    TT
    rs11179002
    CT
    TYR
    rs1393350
    AG
    rs1847134
    AC
    rs1799989
    CC
    GCH1
    rs4411417
    CC ++
    rs752688
    TT ++
    rs8007267
    CT +-
    GCH1.png
    PTS
    rs3819331
    TT
    COMT
    COMT.png

    DBH, GCH1 and COMT might be the biggest problems. I don't have full information about all the SNPs. Maybe you can elaborate it a bit?

    PS: I've had OCD/ADD in the past.

    Thanks.
     
    Last edited: Sep 6, 2015
  2. globalpilot

    globalpilot Senior Member

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    Ontario
    Did you ever resolve your dopamine concerns ? I have the same.
     
  3. TheChosenOne

    TheChosenOne Senior Member

    Messages:
    206
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