What really works for me is lithium, magnesium, phosphatidylcholine, tyrosine and a B complex. Magnesium and lithium increase COMT expression. Phosphatidylcholine helps BHMT, but more importantly, it saves some SAMe. SAMe is needed for COMT to work. Phosphatidylcholine is also very beneficial for my sister, so there must be some genetic benefit. I've run my 23andme file through MTHFRSupport and I was scrolling through it, when I came across an area with a lot of red SNPs in the 'Neurotransmitter Pathway'. I don't think I have a serotonin problem, but I do have a dopamine problem. The SNPs that you were talking about (++, +- and -- are copied from MTHFRSupport): MAOB rs2283729 G rs1799836 C - DDC (This is both AAAD and 5HTD in the pathways below, helping create serotonin and dopamine as well.) rs3735273 CC ++ rs1451375 CC -- rs921451 TT ++ rs2329340 CC rs1451371 CT +- DBH rs77905 AA ++ rs1108580 GG -- rs2007153 CC ++ TPH2 rs4570625 GG rs17110690 GG rs4565946 CT rs10506645 CC rs1487278 TT rs11179002 CT TYR rs1393350 AG rs1847134 AC rs1799989 CC GCH1 rs4411417 CC ++ rs752688 TT ++ rs8007267 CT +- PTS rs3819331 TT COMT DBH, GCH1 and COMT might be the biggest problems. I don't have full information about all the SNPs. Maybe you can elaborate it a bit? PS: I've had OCD/ADD in the past. Thanks.