Now that all the necessary nutrients have been supplied, it was time to give my immune system a kick on the butt. How did I do that? - Low dose naltrexone therapy at night - jump starts your immune system. - Glutathione which you’re already using in Step 1 but it also acts as a potent antiviral / immune booster - High dose vitamin C. Either use the lipophilic form 1000 micrograms daily or more, or order it online and do injections 2-3 times a week. The oral high dose Vitamin C will upset your stomach and the injections are painful as hell - so pick your poison. I guess you can mix injections with lidocaine or apply ice to make it easier. STEP 3. Rest the nervous system (this should be happening simultaneously with STEP 2 or otherwise the program won't work) MAXIMIZE REST, AND YOUR NUTRITION AND HYDRATION!!! ENSURE SUFFICIENT AMOUNT OF DEEP UNINTERRUPTED SLEEP AND AVOID ALL STIMULANTS I put this in caps because I can’t stress this enough. I believe that healing of the body is meant to take place in the parasympathetic mode which is why our normal physical response to illness is minimizing energy and maximizing sleep (which we observe in children and animals but it has unfortunately become lost in frazzled modern homo sapiens species, contributing to rise in chronic infections). I take high dose lipid therapy (fish oil, krill, or primrose) to help repair neuron damage and decrease neuroinflammation. I also like transdermal magnesium oil. Magnesium has a stabilizing effect on nervous system and has good skin absorption. Let's talk about hormones for a moment. Personally, I found that most hormones made me feel better initially but then made me worse in the long run. I do believe now that hypothalamic dysfunction is a protective response of the body to sickness and will correct on its own once you’re better. I am against taking steroids even though my salivary tests were low. I simply didn't find them useful. When it comes to CSF the hormones seem to be not the chicken but the egg, however I believe there is one exception to that rule: pregnenolone. I find pregnenolone beneficial for the following reasons: - it decreases symptoms if PMS which usually aggravates symptoms of CFS for most women - it improves sleep (through progesterone production) - it gets converted to DHEA and cortisol but in safe quantities that your body can regulate on its own - pregnenolone and some of its metabolites act as neurosteroid and help to decrease central nervous system inflammation. (This may also be true for men but I’m not quite as sure about that, I suspect that men may derive similar benefit from testosterone). After several weeks of this immune boosting protocol, I began to experience a mild Herxing reaction as my immune system woke up and started to attack the virus with the new vigor. The symptoms included sore throat, congestion, myalgia, low grade fevers, overall flu-like symptoms. STEP 4 - ANTI-VIRAL THERAPY Now here's the kicker: once I've herxed for a bout a week, I added FAMVIR 250 -500 mg (dependent on your size) three times a day for 14 -21 days. "But wait", some of my savvy readers are probably saying at this point: "I heard that people have to stay on the antiviral therapy for years and that because of that it's very bad, and that some people do it and they don't get better..." All true but what is also true is the fact that most physicians are treating only some parts of CFS but they are not treating the whole spectrum as a disease. CFS is a very complex disease that requires a multisystemic comprehensive approach. My belief is you won't see improvements unless you treat all of the faulty parts simultaneously or in the proper sequential order. In other words, those doctors who focus only on the viral treatment are underestimating the role of the immune system in the recovery. The reason his patients have to stay on the therapy for years is because you can’t win the fight against the chronically dwelling virus without correcting the dysfunctional immune system that led you to becoming chronically infected in the first place and without correcting the major damage, toxicity and depletion brought on by the years of long standing infection. I also suspect that Herxing is often much more severe when you start with heavy guns like anti-virals that will release massive amounts of microbial toxins into your system, and my stepwise approach allows you to lower the viral load through the gentle immune system boost, then purge the rest with antivirals. Most likely antivirals will not clear the virus out of your body entirely but it will lower it enough for the infection to go back to the latent stage and as long as you keep optimizing the status of your immune system it will stay there. I would say that if I had to choose between boosting immune system and taking antivirals, the former is by far a more effective way to go. But the antivirals do help to speed up the process by tipping the battle in favor of your immune system, and Famvir (or other antiviral) taken over a short course has a safety profile that make it a worthwhile addition for most people. STEP 5. GET BETTER AND STAY ON STEPS 1-3 Good luck to you all, I hope someone will find something useful in here.