Hello all, I've recently recieved my 23andMe results which is attached below. However, I'm fairly confused about my combinations and the current consensus (if there is any?) Really hope someone could shed some light on what approach I may take to this. Been reading up a lot and it seems I need to supplement B12 as I have mutations that affects both recycling (MTRR A66G, MTRR A664A) and up-regulation of enzyme (MTR A2756G). The MTHFR A1298C also results in implications for B12, but mainly for folate which I've begun supplementing too. Also have BHMT-08 mutation but guess this is of less concern. Now, I also have a combination of heterozygous (+/-) genes for both COMT V158M and COMT H62H AND homozygous VDR Taq (+/+). My general understanding for heterozygous COMTs is that you would not tolerate methyl groups very well, however, I've also read that my combination with VDR Taq ++ behaves like COMT -/- resulting in a need for methylgroups (?). I might be very wrong in my analysis of my gene combinations, I would really appreciate if anyone could point me in right direction. For instance, should I stick with my methyl-B12 or should I go with hydroxyl-B12 given my COMT and VDR combination? My current daily regime (been taking for 3 days) follow as this: Methyl B12 - 2-3 mg L-methylfolate - 1,6 mg TMG - 500-1000 mg Quercetin 500 mg with vit C PediActive 2xtablets (DMAE and phosphatidylserine) Felt pretty low today and experienced some increased anxiety. First two days went great though. Some speculation could be that I overload on methylgroups. Help is MUCH appreciated!