Hello dear people, I just discovered this website after I received my 23andMe results and would like to ask this amazing community to help me decipher my mutations. I follow mostly vegan diet, with a very rare fish meal (about once every 2 months). I try to lead a very healthy lifestyle with regular yoga and daily mediation sessions. I suffer from quick depletion of stamina, occasional lightheadedness/fainting perhaps due to low iron levels. From the minimal understanding I have, and please correct me if I am wrong, it seems that my vit D machinery is impaired (VDR Taq +/+). Are the COMT, MTRR and BHMT heteros cause of concern too? I already take: - 3000 IU D3 daily. Is this enough or I should ramp up? - fish oil 650mg EPA/450DHA Nordic Naturals Ultimate Omega - 500mcg methylB12 Kirkland (Costco) methylcobalamin - LEF 1xTwo-per-Day multi - 133mg Mg (from Mg glycinate) - Swanson 250mg Bilberry extract, 4mg BioAstin Asthaxanthin, Swanson 20mg Lutein+Zeaxanthin for eye support - 314mg Swanson Strontium Citrate for bone health - 3tbsp of liposomal vitamin C (homemade with sunflower lecithin+sodium ascorbate)=~3g vit C - 2-3 brazil nuts for extra selenium - 1/2 of 225mcg iodine (from kelp) What scares me the most is the CYP1B1 combo of mutations as there is a family history of breast and ovarian issues and from what I understand I am also at very high risk. How bad is CYP2D6 cluster of mutations and what does it mean? I would highly appreciate if you will be kind enough to suggest what would be the best approaches to address these concerns. I am 33/F/, 5' 4" (163 cm), 110 lbs/50kg. Thank you so much for your insight!