When the 'Holiday Season' Is No Holiday at all for Those With ME/CFS
Is December getting to you? Jody Smith shares some thoughts on some of the struggles that all too often attend this time of year ...
Discuss the article on the Forums.

My 23andMe results - how bad are they?

Discussion in 'Genetic Testing and SNPs' started by meche, Nov 3, 2014.

  1. meche

    meche

    Messages:
    2
    Likes:
    0
    Canada
    Hello dear people,

    I just discovered this website after I received my 23andMe results and would like to ask this amazing community to help me decipher my mutations.

    I follow mostly vegan diet, with a very rare fish meal (about once every 2 months). I try to lead a very healthy lifestyle with regular yoga and daily mediation sessions.

    I suffer from quick depletion of stamina, occasional lightheadedness/fainting perhaps due to low iron levels.
    From the minimal understanding I have, and please correct me if I am wrong, it seems that my vit D machinery is impaired (VDR Taq +/+). Are the COMT, MTRR and BHMT heteros cause of concern too?

    I already take:
    - 3000 IU D3 daily. Is this enough or I should ramp up?
    - fish oil 650mg EPA/450DHA Nordic Naturals Ultimate Omega
    - 500mcg methylB12 Kirkland (Costco) methylcobalamin
    - LEF 1xTwo-per-Day multi
    - 133mg Mg (from Mg glycinate)
    - Swanson 250mg Bilberry extract, 4mg BioAstin Asthaxanthin, Swanson 20mg Lutein+Zeaxanthin for eye support
    - 314mg Swanson Strontium Citrate for bone health
    - 3tbsp of liposomal vitamin C (homemade with sunflower lecithin+sodium ascorbate)=~3g vit C
    - 2-3 brazil nuts for extra selenium
    - 1/2 of 225mcg iodine (from kelp)

    What scares me the most is the CYP1B1 combo of mutations as there is a family history of breast and ovarian issues and from what I understand I am also at very high risk.
    How bad is CYP2D6 cluster of mutations and what does it mean?
    I would highly appreciate if you will be kind enough to suggest what would be the best approaches to address these concerns.

    I am 33/F/, 5' 4" (163 cm), 110 lbs/50kg.

    Thank you so much for your insight!
     

    Attached Files:

    Last edited: Nov 4, 2014
  2. Helen

    Helen Senior Member

    Messages:
    2,102
    Likes:
    3,262
    Hi @meche ,

    Welcome to the forum :).
    Did you have any labtests for levels of iron (ferritin) and vitamin B12? You surely know that as you are a vegetarian you are at risk for deficiencies so I think it would be a good idea to start looking here.
    Someone else will hopefully comment on your 23andme test.
     
    meche likes this.
  3. Methyl Health

    Methyl Health

    Messages:
    43
    Likes:
    29
    Your SNPs do not look that bad, you might need more MethylB12 than the 500mcg. I need to take 5000-7000mcg to feel normal but my SNPs are more complicated. But being that you are Vegan it might be something to look at.
     
    meche likes this.
  4. meche

    meche

    Messages:
    2
    Likes:
    0
    Canada
    Thank you @Helen and @Methyl Health for your helpful suggestions!

    Yes, my ferritin levels are a bit lowish (high 20s) - I regularly take pumpkin seeds and black molasses for iron boost.
    My B12 levels were in the 500s last time (1yr ago) but since then I have been taking the 500mcg methyl B12 mentioned+150mcg in the LEF multi.

    My annual tests are due next week so I hope I will come with stable results in those areas.
     
  5. Helen

    Helen Senior Member

    Messages:
    2,102
    Likes:
    3,262
    @meche Your ferritin sounds very low to me. Good that you will have a new test result soon. Post it here with reference ranges and it will probably be commented.
    I agree with Methyl Health that you might need more vitamin B12. The serum B12 is not always reflecting the levels of B12 in tissues.
     

See more popular forum discussions.

Share This Page