1. Patients launch a $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
New Exercise Study Brings Both Illumination and Questions
Simon McGrath looks at new objective evidence of abnormal response to exercise in ME/CFS patients, and the questions that researchers are still trying to answer ...
Discuss the article on the Forums.

My 23andme Results...Any Help Is Appreciated

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by BenRising, Jul 13, 2013.

  1. BenRising

    BenRising

    Messages:
    1
    Likes:
    0
    Hello friends. I have been waiting for these results to return and, though Genetic-Genie comes with some interpretation, I'm eager to receive input from the knowledgeable forum members on these issues. Is there anything of particular importance that I should know or do based on these results? Thank you so very very much for your time and help. BTW- I have been using methyl-folate, and meythl-cobalamin for a few weeks with increasingly promising results; though I have struggled mightily with trying to stay ahead of the low potassium 8-ball.

    Methylation Analysis

    Homozygous (+/+)

    MAO A R297R

    MTRR A66G

    BHMT-02

    BHMT-04

    BHMT-08

    CBS C699T

    Heterozygous (+/-)

    COMT V158M

    COMT H62H

    VDR Bsm

    VDR Taq

    MTHFR C677T

    MTR A2756G

    CBS A360A

    Detox Profile

    Homozygous (+/+)

    CYP1B1 L432V

    CYP2C19*17

    CYP2D6 S486T

    Heterozygous (+/-)

    CYP1A2 164A>C

    CYP2D6 100C>T

    CYP2D6 2850C>T

    NAT2 I114T

    NAT2 K268R
    ---------------------------------
    GSTT1
    Present
    GSTM1
    Present
    G
  2. caledonia

    caledonia

    Messages:
    2,722
    Likes:
    1,314
    Cincinnati, OH, USA
    Start with seeing if CBS is expressed. If so, treat for that first. If you're tolerating the methyl supps (sounds like it?) then you're probably ok. Although Yasko says something about CBS issues possibly showing up later in treatment, if they don't show up right away.

    With a COMT +/- and VDR Taq +/- Yasko is suggesting hydroxycobalamin and adenosylcobalamin, with no methylcobalamin. http://www.scribd.com/doc/132017201/Dr-Amy-s-Simplified-Road-Map-to-Health See the nifty chart about halfway down the page.

    TMG is suggested for the BHMT pathway. I'm having good luck with Yasko's General Health Formula, which has TMG, nucleotides and bunch of other stuff. It gives me a small but nice boost of energy.

    You may want to consider lowering the dose of your methyl supps to keep the potassium thing in control. I've heard that the reason potassium is a problem is due to low magnesium, so you may want to experiment with that too. I seem to be an odd person here - I need to take a ton of magnesium, but my potassium is ok.

    Freddd also has a new thread discussing the potassium issue, and is chalking it up to B complex vitamins, like B2 and the others, but not so much to B12 and folate.

    My magnesium needs got super super high, so I stopped all methylation supps for several days to get it to calm down. Now I'm starting back up each supp one at a time and waiting about 4 days before starting the next one, to see what the culprit is. So far B12 is good.

    For me, a little of everything was good, but once I increased I must have gotten over some kind of threshold and my need for magnesium tripled. Unfortunately, I broke my common sense safety rule and increased 3 different pills at the same time, so now I have to go back and redo it.
  3. Valentijn

    Valentijn Activity Level: 3

    Messages:
    5,885
    Likes:
    7,964
    Amersfoort, Netherlands
    People like to freak out about CBS C699T, based on a completely inapplicable study. One study shows that the +/+ version is associated with reduced risk of folate-related birth defects, and another shows it's associated with increase risk of some type of cancer (not surprising since cancer cells enjoy the benefits of good methylation as much as normal cells do). So for methylation purposes, you probably have the better version of that SNP.

    BHMT-08 has a minor effect on gene function. The other BHMTs do not.

    Homozygous MTRR A66G does have some effect on gene function, and increases the risk of low-folate/high-homocysteine associated birth defects.

    All versions of MAOA are very common, and each is associated with small risk factors for different mental illness. The homozygous version you have is the slower version, so your catecholamines don't break down quickly. Some people think this means that supplementing with methyl groups or catecholamine precursors is a bad idea, and should be undertaken with caution, if at all.

    The heterozygous COMTs are irrelevant.

    VDR Bsm is the same as VDR Taq, except it's reported backwards. While it does reflect the activity of Taq accurately, having variations in both VDR SNPs is no more relevant than having a variation in one of the VDR SNPs. It's not clear if heterozygous VDR Taq has any impact, but might cause slightly lower vitamin D 25.

    Heterozygous MTHFR C677T usually means reduced activity, at about 65% of normal. So supplementing a normal dose of methylfolate could be very helpful (if going higher, you might want to be careful due to excess methyl groups potentially causing problems with slow catecholamine break down due to your version of MAOA).

    Heterozygous MTR might or might not be a problem. No indication that it has a big impact.
    sregan likes this.
  4. jimells

    jimells Senior Member

    Messages:
    347
    Likes:
    413
    northern Maine
    Valentijn Wow - very impressive! How does anyone keep all that stuff straight? I just ordered the $99 23andme.com test. It will be interesting to see what it reveals...
  5. Valentijn

    Valentijn Activity Level: 3

    Messages:
    5,885
    Likes:
    7,964
    Amersfoort, Netherlands
    Mostly people don't keep them straight and just parrot what Yasko says :p I prefer to read the actual research, which is a lot more relevant and accurate.
    jimells likes this.

See more popular forum discussions.

Share This Page