The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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Muscles pain, weakness, cramps. Diamox vs Mestinon

Discussion in 'General Treatment' started by pattismith, Dec 10, 2017.

  1. pattismith

    pattismith Senior Member

    Diamox (acetazolamide) , and other carboxic anhydride inhibitors , are diuretics which si used to treat HPP (hypokalemia periodic paralysis). This disease is a genetic muscle channelopathy.

    Mestinon (pyridostigmine) and other cholinesterase inhibitors are used to treat MG (myasthenia gravis), an auto-immune disease.

    Both diseases induce muscle weakness and are sensitive to low blood potassium, but two interesting things can help to diferenciate, apart from specific diagnostic tests:

    Diamox can worsen MG
    Mestinon cannot help HPP and can worsen it

    I have tryed both Mestinon-like drug and Diamox and after a few days I can say only Diamox helps me.
    One interesting thing I noticed is that almost immediatly I was able to walk better and that my hips better fit in their socket (much less "cloc " when moving), so obviously my muscle strenght improved. I don't think that I have HPP, but impairment of some ion-channel yes.

    I may have this problem for a long time but it was dramatically worsen by the long antibiotic treatment I had with azythromycin and Doxycycline, this is why I wanted to share my finding and experimentation.
    Last edited: Dec 11, 2017
    Aroa, Shoshana, Learner1 and 2 others like this.

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