Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Muscles pain, weakness, cramps. Diamox vs Mestinon

Discussion in 'General Treatment' started by pattismith, Dec 10, 2017.

  1. pattismith

    pattismith Senior Member

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    Diamox (acetazolamide) , and other carboxic anhydride inhibitors , are diuretics which si used to treat HPP (hypokalemia periodic paralysis). This disease is a genetic muscle channelopathy.

    Mestinon (pyridostigmine) and other cholinesterase inhibitors are used to treat MG (myasthenia gravis), an auto-immune disease.

    Both diseases induce muscle weakness and are sensitive to low blood potassium, but two interesting things can help to diferenciate, apart from specific diagnostic tests:

    Diamox can worsen MG
    Mestinon cannot help HPP and can worsen it

    I have tryed both Mestinon-like drug and Diamox and after a few days I can say only Diamox helps me.
    One interesting thing I noticed is that almost immediatly I was able to walk better and that my hips better fit in their socket (much less "cloc " when moving), so obviously my muscle strenght improved. I don't think that I have HPP, but impairment of some ion-channel yes.

    I may have this problem for a long time but it was dramatically worsen by the long antibiotic treatment I had with azythromycin and Doxycycline, this is why I wanted to share my finding and experimentation.
     
    Last edited: Dec 11, 2017
    Aroa, Shoshana, Learner1 and 2 others like this.

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