Diamox (acetazolamide) , and other carboxic anhydride inhibitors , are diuretics which si used to treat HPP (hypokalemia periodic paralysis). This disease is a genetic muscle channelopathy. Mestinon (pyridostigmine) and other cholinesterase inhibitors are used to treat MG (myasthenia gravis), an auto-immune disease. Both diseases induce muscle weakness and are sensitive to low blood potassium, but two interesting things can help to diferenciate, apart from specific diagnostic tests: Diamox can worsen MG Mestinon cannot help HPP and can worsen it I have tryed both Mestinon-like drug and Diamox and after a few days I can say only Diamox helps me. One interesting thing I noticed is that almost immediatly I was able to walk better and that my hips better fit in their socket (much less "cloc " when moving), so obviously my muscle strenght improved. I don't think that I have HPP, but impairment of some ion-channel yes. I may have this problem for a long time but it was dramatically worsen by the long antibiotic treatment I had with azythromycin and Doxycycline, this is why I wanted to share my finding and experimentation.