Heat shock proteins... as usual all roads end up getting very tangled. The heat shock proteins come into play as part of the body's defensive reaction, their role is to protect proteins from being unfolded and otherwise damaged by the threats of heat and oxidation, etc. Apparently, you can think of them as providing a protective covering to the proteins. As to why that would protect them fro heat for more than a millisecond, I don't know. So, if NSAIDS reduce the amount of HSPs being produced, the tight junctions in the gut don't get protected so well from heat or oxidation or whatever.