Hi everyone, I've been trying to tweak a methylation protocol for several months tapering up my doses to see if I can get noticeable effects. Since I've started I've had an improvement in my overall mood, depression, etc, but lack any clear outright effects that some people seem to have. I do believe I have an overall increase in energy and for sure in improvement in mental stability. My biggest problem is my IBS has worsened and it seems like my muscle recovery has become quite worse, and I fin myself waking up with sore legs, arms and pain in my knees. I'm hoping it will go away and plan on continuing the protocol for a while longer to see if its temporary, but wanted to see if anyone has recommendations that could help. MB12 and ADB12 - 2 x B12 Oil Spray per Day on average, plus tweaking up with as high as an additional 10000mcg sublingual per each type on different days to test effects. Have tried 50,000mcg ADB12 in one day without seeing a major effect. Methylfolate - Average of 8000mcg per day LCF - Now at 1000mg L-Carnitine/2 pills of Doctor's best (No major noticeable effect) B-Complex - http://www.vitacost.com/thorne-research-stress-b-complex-60-vegetarian-capsules-1 Potassium - At least 1000mg per day and increase depending on symptoms Other Supplements Taken And Continued Before Starting Vitamin C - 1000mg Vitamin D - 10,000IU Curcumin - 1000mg Magnesium 400mg Symptoms I'm Trying To Treat Include: Chronic Fatigue Muscle Weakness Headaches Blurred Vision and Photophobia IBS In terms of genetics in case it helps I have: MTHFR C677T +/+ COMT V158M and H62H +/- MTR A2756G +/- MTRR A66G +/- MTRR A664A +/- CBS C699T +/- Could there be some factor I'm missing? Should I try raising doses higher, or lowering some? Any advice is greatly appreciated.