Been addressing my MTR/MTRR by taking TMG but somewhat confused about what my results so far mean. I'm taking a very small amount 125 mg 1x a day. So far it seems to be a mixed bag of side effects. My mornings are unbelievably not normal for me in a good way…….wake up early, feel refreshed, mind clear, good energy. But by the end of the day I feel flat and depressed which is also not my normal pattern. My +/+ status on MTR/MTRR and my elevated homocysteine led to my decision to give TMG a try but I am not sure how to interpret the results of taking it, and how to proceed. stop? take it 2x a day instead of 1x? take less? Anyone else with MTR/MTRR issue trying TMG or anything else to address MTR/MTRR? Theres not as much activity& info on the forum regarding MTR/MTRR like there is with CBS, COMT & MTHFR and I would like to understand more about it.