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MTHFR Pyridoxine HCL

Discussion in 'Genetic Testing and SNPs' started by dobson116, Jan 20, 2015.

  1. dobson116

    dobson116

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    What happens when someone with an MTHFR mutation takes pyridoxine HCL instead of P5P? Is it harmful?
     
  2. Sherpa

    Sherpa Ex-workaholic adrenaline junkie

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    I have taken it in moderate doses (up to 100mg) with no ill effects. I respond to P5P better.
     
  3. dobson116

    dobson116

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    Hmmm... the reason I ask is that I usually have no dream recollection.

    I am wondering now if it is possible that I have pyroluria... I have all the symptoms. My Spectracell showed that I am actually low in copper, and fine on b6 and zinc. It makes me wonder how accurate those

    Would it make sense to supplement with something like Jarrow Zinc balance since I'm not actually sure if I have pyroluria or not?
     
  4. Sherpa

    Sherpa Ex-workaholic adrenaline junkie

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    Starting at around 100mg p5p my dream recall comes back and stays there every night. I like that.

    I go by symptoms more than lab tests. My pyroluria lab test came back negative, but I have all the symptoms and feel MUCH better on zinc (15mg) and p5p so I take it. In fact I can hardly handle going off it. If I have severe stress my b6 deficiency symptoms (insomnia and vocal tics) return.


    I have no idea how accurate spectracell is. I have not heard it recommended by any top CFS / pyroluria docs...not to say it isn't good or maybe just unknown by me.

    As far as zinc, I don't like to take anything with copper in it (I tested high). Maybe the Jarrow Stuff with 1mg copper is ok for you? I like Pic Mins by Thorne..containing 15mg of zinc picolinate and trace minerals. Too much supplemental zinc.. Like 30mg..causes metal (copper? Lead?) detox symptoms in me..agitation, poor decision making ability, etc
     
    Last edited: Jan 21, 2015
  5. Gondwanaland

    Gondwanaland Senior Member

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    Pairing B6 with magnesium helps with dream recall.
     
  6. Critterina

    Critterina Senior Member

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    I also took 100 mg of pyridoxine HCl without ill effect, but it didn't cure my functional B6 deficiency. I had to take P5P for that, and 50 or 100 mg does it.
     

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