MTHFR Mutation...do you know about this?

[Misfit Toy]

My doctor had my do a blood test to find out if I have the MTHFR Mutation. Does anyone else have this, know about it, etc? Is this old news? I came up that I am positive for it.

I have to take 5 MTHF. Any insight would be welcomed.

I think it's just what we always knew we have. Problems with detoxing.

 

[Sushi]

My doctor had my do a blood test to find out if I have the MTHFR Mutation. Does anyone else have this, know about it, etc? Is this old news? I came up that I am positive for it.

I have to take 5 MTHF. Any insight would be welcomed.

I think it's just what we always knew we have. Problems with detoxing.

Well, this isn't exactly "old news," but it has been discussed here a great deal. Many here have one of the two most common MTHFR mutations, and if you do a google search of this site, you will find many threads on it. This mutation is significant for methylation function, and yes, it would mean that you may not be able to make the folate conversions necessary to make 5 MTHF.

But you should probably read up on methylation too as you most likely have a methylation block and will need to take active B12 and other supplements to try to correct this.

Best wishes with this,
Sushi

 

[triffid113]

The 5MTHF is the over the counter Solgar Metafolin many of us hae been taking for years.

 

[taniaaust1]

It's old news.. many of us here have this including myself. The polymorphism caused me to have a disabled/disfigured child (which a condition similar to spinia bifida). Ive heard that it is the most common cause of miscarriage (which can happen anytime up to birth) when there is actually nothing at all wrong with the baby..issue is with mother alone...anyone who miscarriages should be tested for this polymorphism.
It puts you at a much higher risk of many things eg strokes and affects the methylation cycle.

What is VERY IMPORTANT is that thou some doctors know to get people tested for it.. they may not be at all up to date on the treatment for it.

More is needed to treat this for the first couple of years at least.. then just active folate form. (as my MTHFR specialist says it takes up to two years for the body to start using that active folate pathway properly even when the active folate is given to bypass where this polymorphism occurs in the DNA.. hence a need for methylB12 which the body will use while its adjusting to the change). Ive written about MTHFR quite a few times in my thread in the treatment section of the forum.

Note.. a so called but not up to date specialist was treating my MTHFR and I had no change at all so thought I'd ruled out this causing any of my issues. I thou found out throu an expert at the MTHFR website expert that the things I'd been put on for it were completely wrong forms of things so sought out another MTHFR specialist to go and see for advice. Sure enough.. he said too that the previous specialist had me on the wrong things. Its a pity as I could of been being treated for this 5 years or so ago but now are only just being treated for it now. And its certainly helping me very much the correct treatment.. far more stamina.. far far less heat intollerance, it even seems to be helping my POTS. (it "may" be helping my circardian rythmn issue and my brain too but Im still trying to figure that out to be sure).

Do your research and make sure the treatment you are being given for this is up to date and correct. Note..there is more then one different type of MTHFR polymorphism.

MTHFR isnt uncommon (between 9-18% of healthy people have this depending on what country you are in) but I suspect it the rates of it may be far higher in our ME/CFS communities being a methylation issue. So suggest that everyone here should be tested for this.

**thou this affects folate and I obviously had my folate affected enough to have my babes spine severely affected by it.. Ive never had an abnormal folate test. (Homocysteine test thou can give very strong clue to if someone probably has this EVEN WHEN IN THE NORMAL RANGE if you know what numbers to be looking for...its how my specialist first relalized i had this).

 

[ukxmrv]

I was tested in around 2002. Dr Cheney at the time said he was seeing these mutation in his CFS patients.

 

[chilove]

Yes, I have the double MTHFR mutation and have been on a methylation protocol for about a year. I'm doing much better generally now after some corrective measures and getting my amalgam fillings removed.