My post has been transferred to the "Introduce Yourself" section, so I post it again here and hope I get some comments: Hello together, I have been ill for a long time (20 years, now 34 years old) and maybe have CFS – maybe not. I fullfill most of the criteria for CFS, but not the major criteria of post exertional malaise, which led one of my doctors to the hypothesis of „untypical“ CFS. I’m also in treatment by a infectious disease specialist, who found multiple chronic bacterial infections (Chlamydia pneumoniae, Pseudomonas aeruginosa, Klebsiella oxytoca). So it seems that my body cannot fight off special kinds of bacteria. As far as I know, Chlamydia pneumoniae has been described as a possible cause for CFS. I had extensive diagnostics for immune defects, but all tests came back normal (just very low CD57+ killer cells, which has been described in Lyme disease but is most likely not specific for this disease). Recently, I got back my results from 23andme, and I’m not sure how they might be related to my illness. Some of the methylation results from Genetic Genie are: MTHFR C677T rs1801133 AA +/+ MTHFR 03 P39P rs2066470 GG -/- MTHFR A1298C rs1801131 TT -/- MTR A2756G rs1805087 AA -/- MTRR A66G rs1801394 AG +/- MTRR H595Y rs10380 __ no call MTRR K350A rs162036 AA -/- MTRR R415T rs2287780 __ no call MTRR A664A rs1802059 GG -/- BHMT-02 rs567754 TT +/+ BHMT-04 rs617219 __ no call BHMT-08 rs651852 TT +/+ So it seems that I do have a homozygous defect in MTHFR and in BHMT-02 and BHMT-08. I’m not sure what the defect in BHMT has to say. Is it possible that these defects can have an impact on the immune system, so that these could be a case for may chronic infections? I have tried in the past (without knowing the test results above) 1 mg Methyl-B12 sublingual ones or twice a day. Short time after (30 minutes or so) I got more energy and felt quite better, but after a few hours I developed flulike symptoms with a runny nose and more fatigue which made me stop the supplements after a few days. Thanks for reading my post until here. Thankful about every hint you might give me.