Hi all Hope someone can help please - I posted here once before and the comments were very helpful indeed and I'm very grateful. I have had some issues with adrenals, fatigue, erratic blood sugar and poor digestion, but my reason for posting was blood test with very high folate levels and yet apparently normal b12 which seemed odd. Upon recommendation here I got some further tests... 'Active' B12 - is apparently perfectly ok (although I did take some methylb12 1000mcg for a few weeks, then stopped for several weeks prior to the test so wonder if test was compromised depending on half-life) and my homocysteine was fine (6). However the following came up: MTHFR test - I am heterozygous for A12898C, no other mutations. Genova MAP test - indicated I am low in most B vitamins and have high Beta-Hydroxybutyric Acid in urine for some reason. Thyroid - fine Plasma test - low in magnesium (despite supplementation of magnesium citrate/malate for years), low in zinc (despite supplementation for 12 months) and low in manganese. Everything else ok apart from slightly low iron (which was fine in last test). Histamine - high Pyroluria - negative Serum folate - normal (highish but had come down since I started taking methylB12 and stopped taking Wellman multi) So it was suggested I do have a methylation issue, mainly due to historic adrenal stress which takes a considerable while to recover and B-vitamins will help this. The suggestion is that my adrenals are still a bit weak, which causes the zinc/magnesium loss and impaired digestion. Makes sense to me but I don't think anyone I know can tell me much about MTHFR. My query is that if I am HETEROZYGOUS A12898C, am I supposed to take 'folic acid' to help this or not? Should I take methylfolate (last time I took this it gave me insomnia off a small dose) or do I not need any supplemental folate of any kind and just get it from diet. I see a lot of stuff about methylfolate for those with the other mutation but not sure what the strategy is for mine so would appreciate any advice. Thanks very much indeed for any help!