I would absolutely exercise to collapse in order to get the data we patients need. I'm at the age where I'm not going to get my career back even if I achieved complete remission in the next couple of years (which I doubt is going to happen). I've already been severely ill, and though I expect I'm going to seriously dislike it if I have a long-term crash, I also have learned a lot about getting through (and past) a crash. Most importantly, I have a spectacular doctor in Dr Rey, who I am confident would do what it takes to help me improve my health afterwards. I'm looking at the benefit to the young people -- including my ME/CFS afflicted 20yo -- that can be achieved through the participation of more severely affected patients. We've had too many studies composed of mildly affected patients because the more severely ill among us are rightly concerned about the potential damage to our long-term health. Unfortunately, I'm not in NY and I already have an ME/CFS doctor that I don't want to change. I'll keep an eye on the study though and if I can find a way to participate, I will.