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Mouse models are rubbish models of neurodegenerative disease

Discussion in 'Other Health News and Research' started by Ecoclimber, Apr 10, 2015.

  1. Ecoclimber

    Ecoclimber Senior Member

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    .Premission to repost by Prof. Gavin Giovannoni

    There are some in the ME/CFS medical field that believe ME/CFS is 'MS Light' or 'Atypical MS'. Dr. Hornig alluded to this fact recently. The reason I post these articles is the fact that research in one area may spill over into another area of research or the fact that researchers reviewing a site may look at the research in another disease category that could be related to theirs and it might raise their interest level.

    Burns TC, Li MD, Mehta S, Awad AJ, Morgan AA.Mouse models rarely mimic the transcriptome of Human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models. Eur J Pharmacol. 2015. pii: S0014-2999(15)00236-8

    Translational research for neurodegenerative disease depends intimately upon animal models. Unfortunately, promising therapies developed using mouse models mostly fail in clinical trials, highlighting uncertainty about how well mouse models mimic human neurodegenerative disease at the molecular level.

    We compared the transcriptional signature of neurodegeneration in mouse models of Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS) to human disease.

    In contrast to aging, which demonstrated a conserved transcriptome between humans and mice, only 3 of 19 animal models showed significant enrichment for gene sets comprising the most dysregulated up- and down-regulated human genes.

    It was revealed even healthy human aging to be more closely related to human neurodegeneration than any mouse model of AD, PD, ALS or HD.

    Remarkably, mouse models frequently upregulated stress response genes that were consistently downregulated in human diseases. Among potential alternate models of neurodegeneration, mouse prion disease outperformed all other disease-specific models.

    Even among the best available animal models, conserved differences between mouse and human transcriptomes were found across multiple animal model versus human disease comparisons, surprisingly, even including aging.

    Relative to mouse models, mouse disease signatures demonstrated consistent trends towards preserved mitochondrial function protein catabolism, DNA repair responses, and chromatin maintenance.

    These findings suggest a more complex and multifactorial pathophysiology in human neurodegeneration than is captured through standard animal models, and suggest that even among conserved physiological processes such as aging, mice are less prone to exhibit neurodegeneration-like changes.

    This work may help explain the poor track record of mouse-based translational therapies for neurodegeneration and provides a path forward to critically evaluate and improve animal models of human disease.

    Comments from MouseDoctor:
    We have been here before. When human inflammatory response genes were compared with mouse inflammatory gene responses there was no similarity and here neurodegenerative disease from humans were compared to animal models and there was no correlation.

    Is this why animals models don't predict treatment success in humans. Maybe....however, our animal MS models predicted the failure of Gilenya in progressive MS. If we compare chalk with cheese, we get mushroom food, but is it really the case that animal studies can't predict responses in humans....I think not. I bet they can.

    However, at the same time we need to accept that models are models and not the same as human disease and this study will be used as yet another nail in the coffin of animal studies.

    However animals are not humans.
     
    Last edited: Apr 10, 2015
    barbc56, NK17, Sean and 4 others like this.
  2. Beyond

    Beyond Juice Me Up, Scotty!!!

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    Murcia, Spain
    More and more the scientific community will acknowledge the (partial) futility of the animal model. However, we are faced with the problematic of not being able to reproduce many of the experiments with humans.

    No one will (at least officially! o_O) cause intentionally IBD to human subjects to test if curcumin alleviates it or not. I don´t think is correct to do that animals by the way.
     
    barbc56 likes this.

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