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- 1
Hello, I was referred here by a friend who told me people here love friendly dissection of 23andme data and relevant variant app results. If by chance you enjoy that, by all means please take a crack at me; trying as hard as I can to figure it out. I would be eternally grateful for any potshots, guestimates, crackpot theories, second hand rumors, or complete fantastical postulates. I would also just like to describe my profile in case anyone out there has a similar one. Sincerely thankful if anyone takes a minute on this. I've been lurking a long while. Apologies if I stepped over any boundaries or rules, I'll fix if so. I have been through Caledonia's guide, it's just I have so many that the combinations are becoming incredibly confusing, so I figured I'd post. Again, I'm not asking for help if you find SNP threads overwhelming
Symptoms:
ADHD (diagnosed)
Anxiety (diagnosed)
Depression (diagnosed)
Low Motivation
Low Libido
Acute Unexplained Joint Pain (multiple top surgeons, surgeries unsuccessful)
Clues:
Testosterone: 600ng/dl [350-1200] Free: 15.8pg/ml [9.3-26.5]
TSH: 0.673uiu/ml [0.450-4.5]
LH: 5.0miu/ml [1.7-8.6]
FSH: 3.1 [1.5-12.4]
Lyme negative
Rheumatoid negative
ANA negative
Celiac negative
Lots of Methylfolate or Methyl B-12 give me prickly overload sensations, awful
Initial Sulfur Urine Strip: >1600
Current Sulfur Urine Strip: around > or = 800
Diet most of life was fried foods, crap, mostly meat and breads
Diet for the last week gluten/dairy free, low protein
GABA gives me prickly overload sensations much worse than methyl groups
Supplements:
Quatrefolic 800mcg 2x/d --- tolerated at this dose, not much higher
Hydroxo B-12 4000mcg 2x/d --- well tolerated at this dose
Molybdenum 1000mcg 2x/d --- well tolerated at this dose
Yucca 1.5g 2x/d --- well tolerated at this dose
DHA/EPA 560/100mg 2x/d --- well tolerated at this dose
Royal Jelly 500mg 2x/d --- well tolerated at this dose
Boron 6mg 2x/d --- caused 2 day massive spike in libido, then return to no libido
Cal-Mag-Zinc 1000/500/25mg 2x/d --- well tolerated at this dose
Allergy:
HLA + / -
Clotting Factors:
CETP + / -
CYP4V2 + / -
F10 + / -
HRG +/ -
NR1I2 + / -
Detox:
CTH + / +
CYP2D6 T2850C + / -
NAT2 + / -
Gluten Intolerance:
HLA-DQA1 + / +
IGA:
HLA-DQA2 + / +
IFIH1 + / +
MTC03P1 + / +
MTC03P1 + / + (two rs ids, AA, CC)
IGF1R + / -
IRF5 + / -
TRAF1 + / -
IGE:
FCER1A + / +
RAG1 + / +
C3 + / -
FCER1A + / - (another rs)
IL5 + / -
RAD50 + / -
SOCS1 + / -
IGG:
GSTM3 + / -
METHYLATION:
AGT M235T/C4072T + / +
BHMT-02 + / +
BHMT-08 + / +
CBS A13637G + / +
FOLR2 + / +
GAD1 + / +
GAD1 + / +
GAD1 + / + (3 rs ids)
MAOB + / + (I know this is recorded differently. GGenie has it MAOA ++)
MTHFR C677T + / +
Ace Del16 + / -
AHCY-01 + / -
AHCY-19 + / -
CBS C19150T + / -
CBS C699T + / -
DAO + / -
FUT2 + / -
FUT2 + / -
FUT2 + / -
GAD1 + / -
GAD1 + / -
GAD1 + / - (3 rs ids)
GIF + / -
MIR4761COMT H62H + / -
MIR4761COMT V158M + / -
MIR4761COMT + / -
MTHFD1 C105T + / -
MTHFD1 G1958A + / -
MTHFS + / -
MTR A2756G + / -
MTR A66G + / -
MTR-11 A664A + / -
NOS2 + / -
PEMT + / -
SOD3 + / -
TCN2 C766G + / -
VDR Bsm + / -
VDR Tak + / -
Mitochondrial Function:
NDUFS7 + / +
NDUFS7 + / +
NDUFS7 + / + (3 rs ids)
SLC19A1 + / -
Other Immune Factors:
APOE + / -
ATG16L1 + / -
TNF + / -
TNF + / - (2 rs ids)
Sulfurotransferase:
SULT2A1 + / -
Symptoms:
ADHD (diagnosed)
Anxiety (diagnosed)
Depression (diagnosed)
Low Motivation
Low Libido
Acute Unexplained Joint Pain (multiple top surgeons, surgeries unsuccessful)
Clues:
Testosterone: 600ng/dl [350-1200] Free: 15.8pg/ml [9.3-26.5]
TSH: 0.673uiu/ml [0.450-4.5]
LH: 5.0miu/ml [1.7-8.6]
FSH: 3.1 [1.5-12.4]
Lyme negative
Rheumatoid negative
ANA negative
Celiac negative
Lots of Methylfolate or Methyl B-12 give me prickly overload sensations, awful
Initial Sulfur Urine Strip: >1600
Current Sulfur Urine Strip: around > or = 800
Diet most of life was fried foods, crap, mostly meat and breads
Diet for the last week gluten/dairy free, low protein
GABA gives me prickly overload sensations much worse than methyl groups
Supplements:
Quatrefolic 800mcg 2x/d --- tolerated at this dose, not much higher
Hydroxo B-12 4000mcg 2x/d --- well tolerated at this dose
Molybdenum 1000mcg 2x/d --- well tolerated at this dose
Yucca 1.5g 2x/d --- well tolerated at this dose
DHA/EPA 560/100mg 2x/d --- well tolerated at this dose
Royal Jelly 500mg 2x/d --- well tolerated at this dose
Boron 6mg 2x/d --- caused 2 day massive spike in libido, then return to no libido
Cal-Mag-Zinc 1000/500/25mg 2x/d --- well tolerated at this dose
Allergy:
HLA + / -
Clotting Factors:
CETP + / -
CYP4V2 + / -
F10 + / -
HRG +/ -
NR1I2 + / -
Detox:
CTH + / +
CYP2D6 T2850C + / -
NAT2 + / -
Gluten Intolerance:
HLA-DQA1 + / +
IGA:
HLA-DQA2 + / +
IFIH1 + / +
MTC03P1 + / +
MTC03P1 + / + (two rs ids, AA, CC)
IGF1R + / -
IRF5 + / -
TRAF1 + / -
IGE:
FCER1A + / +
RAG1 + / +
C3 + / -
FCER1A + / - (another rs)
IL5 + / -
RAD50 + / -
SOCS1 + / -
IGG:
GSTM3 + / -
METHYLATION:
AGT M235T/C4072T + / +
BHMT-02 + / +
BHMT-08 + / +
CBS A13637G + / +
FOLR2 + / +
GAD1 + / +
GAD1 + / +
GAD1 + / + (3 rs ids)
MAOB + / + (I know this is recorded differently. GGenie has it MAOA ++)
MTHFR C677T + / +
Ace Del16 + / -
AHCY-01 + / -
AHCY-19 + / -
CBS C19150T + / -
CBS C699T + / -
DAO + / -
FUT2 + / -
FUT2 + / -
FUT2 + / -
GAD1 + / -
GAD1 + / -
GAD1 + / - (3 rs ids)
GIF + / -
MIR4761COMT H62H + / -
MIR4761COMT V158M + / -
MIR4761COMT + / -
MTHFD1 C105T + / -
MTHFD1 G1958A + / -
MTHFS + / -
MTR A2756G + / -
MTR A66G + / -
MTR-11 A664A + / -
NOS2 + / -
PEMT + / -
SOD3 + / -
TCN2 C766G + / -
VDR Bsm + / -
VDR Tak + / -
Mitochondrial Function:
NDUFS7 + / +
NDUFS7 + / +
NDUFS7 + / + (3 rs ids)
SLC19A1 + / -
Other Immune Factors:
APOE + / -
ATG16L1 + / -
TNF + / -
TNF + / - (2 rs ids)
Sulfurotransferase:
SULT2A1 + / -