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Mother-lode? How'd you approach these SNPs :(

Discussion in 'Genetic Testing and SNPs' started by allscarredup, Dec 4, 2014.

  1. allscarredup

    allscarredup

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    Hello, I was referred here by a friend who told me people here love friendly dissection of 23andme data and relevant variant app results. If by chance you enjoy that, by all means please take a crack at me; trying as hard as I can to figure it out. I would be eternally grateful for any potshots, guestimates, crackpot theories, second hand rumors, or complete fantastical postulates. I would also just like to describe my profile in case anyone out there has a similar one. Sincerely thankful if anyone takes a minute on this. I've been lurking a long while. Apologies if I stepped over any boundaries or rules, I'll fix if so. I have been through Caledonia's guide, it's just I have so many that the combinations are becoming incredibly confusing, so I figured I'd post. Again, I'm not asking for help if you find SNP threads overwhelming

    Symptoms:
    ADHD (diagnosed)
    Anxiety (diagnosed)
    Depression (diagnosed)
    Low Motivation
    Low Libido
    Acute Unexplained Joint Pain (multiple top surgeons, surgeries unsuccessful)

    Clues:
    Testosterone: 600ng/dl [350-1200] Free: 15.8pg/ml [9.3-26.5]
    TSH: 0.673uiu/ml [0.450-4.5]
    LH: 5.0miu/ml [1.7-8.6]
    FSH: 3.1 [1.5-12.4]
    Lyme negative
    Rheumatoid negative
    ANA negative
    Celiac negative

    Lots of Methylfolate or Methyl B-12 give me prickly overload sensations, awful
    Initial Sulfur Urine Strip: >1600
    Current Sulfur Urine Strip: around > or = 800
    Diet most of life was fried foods, crap, mostly meat and breads
    Diet for the last week gluten/dairy free, low protein
    GABA gives me prickly overload sensations much worse than methyl groups

    Supplements:
    Quatrefolic 800mcg 2x/d --- tolerated at this dose, not much higher
    Hydroxo B-12 4000mcg 2x/d --- well tolerated at this dose
    Molybdenum 1000mcg 2x/d --- well tolerated at this dose
    Yucca 1.5g 2x/d --- well tolerated at this dose
    DHA/EPA 560/100mg 2x/d --- well tolerated at this dose
    Royal Jelly 500mg 2x/d --- well tolerated at this dose
    Boron 6mg 2x/d --- caused 2 day massive spike in libido, then return to no libido
    Cal-Mag-Zinc 1000/500/25mg 2x/d --- well tolerated at this dose

    Allergy:
    HLA + / -

    Clotting Factors:
    CETP + / -
    CYP4V2 + / -
    F10 + / -
    HRG +/ -
    NR1I2 + / -

    Detox:
    CTH + / +
    CYP2D6 T2850C + / -
    NAT2 + / -

    Gluten Intolerance:
    HLA-DQA1 + / +

    IGA:
    HLA-DQA2 + / +
    IFIH1 + / +
    MTC03P1 + / +
    MTC03P1 + / +
    (two rs ids, AA, CC)
    IGF1R + / -
    IRF5 + / -
    TRAF1 + / -

    IGE:
    FCER1A + / +
    RAG1 + / +

    C3 + / -
    FCER1A + / - (another rs)
    IL5 + / -
    RAD50 + / -
    SOCS1 + / -

    IGG:
    GSTM3 + / -

    METHYLATION:
    AGT M235T/C4072T + / +
    BHMT-02 + / +
    BHMT-08 + / +
    CBS A13637G + / +
    FOLR2 + / +
    GAD1 + / +
    GAD1 + / +
    GAD1 + / +
    (3 rs ids)
    MAOB + / + (I know this is recorded differently. GGenie has it MAOA ++)
    MTHFR C677T + / +
    Ace Del16 + / -
    AHCY-01 + / -
    AHCY-19 + / -
    CBS C19150T + / -
    CBS C699T + / -
    DAO + / -
    FUT2 + / -
    FUT2 + / -
    FUT2 + / -
    GAD1 + / -
    GAD1 + / -
    GAD1 + / - (3 rs ids)
    GIF + / -
    MIR4761COMT H62H + / -
    MIR4761COMT V158M + / -
    MIR4761COMT + / -
    MTHFD1 C105T + / -
    MTHFD1 G1958A + / -
    MTHFS + / -
    MTR A2756G + / -
    MTR A66G + / -
    MTR-11 A664A + / -
    NOS2 + / -
    PEMT + / -
    SOD3 + / -
    TCN2 C766G + / -
    VDR Bsm + / -
    VDR Tak + / -

    Mitochondrial Function:
    NDUFS7 + / +
    NDUFS7 + / +
    NDUFS7 + / +
    (3 rs ids)
    SLC19A1 + / -

    Other Immune Factors:
    APOE + / -
    ATG16L1 + / -
    TNF + / -
    TNF + / - (2 rs ids)

    Sulfurotransferase:
    SULT2A1 + / -
     

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