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In Brief: The Adrenal Glands and ME
The second in a new series of ‘In Brief’ articles, where Andrew Gladman provides a helpful insight into the science behind fairly common topics, exploring how they relate to ME/CFS. This time he discusses the adrenal glands and why they can be such a talking point ...
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more psychiatric fairy stories

Discussion in 'General ME/CFS News' started by Gerwyn, Feb 1, 2010.

  1. Gerwyn

    Gerwyn Guest

    A number of studies sponsored by our friends in psychiatry have quoted r values in their claims re causative factors in Me/cfs

    for a start r referrs to correlation not causation if there is a strong correlation r must be greater than 0.8 any thing less than 0.5 is weak the lower the weaker.It is quite possible to get a very small pvalue but a very weak correlation

    They also can quote confidence intervals----this is actually difficult to describe think of it as a measure of how confident you are that the result is representative of a population and its relatively safe to generqalise from it.In science this normally means that the scatter of your data must be no more than 5% either side of your mean or average value

    If you look at the data published by Heim et al claiming a six fold increase in cfs symptoms in those suffereing from self reported child abuse the r value was0.3

    and the confidence intervals varied about 70% on each side of the mean that was somehow skewed If I continued to produce fairy stories I,d probably be sectioned----could I suggest the same treatment here!

    Saying that cfs symptoms are 6times more likely to occur in patients with CFS than healthy controlls with such a small r value is a little like saying that the symptoms of depression are 6 times more likely than in people who dont have depression!
  2. V99

    V99 *****

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    I never knew there was so much to learn about fairies. Where is the fairy smilie when you need them.

    Thank you for that explanation. I have heard about the, less than 0.5 is weak, but what is a p value?
  3. Gerwyn

    Gerwyn Guest

    Hi v99 p is a measure of probability of the result being due to chance alone A p value has to be less than .05 to be significant this means that the probability of a result occuring purely by chance is less than 5 in a hundred
  4. V99

    V99 *****

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    Than you Gerwyn.

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