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The Fable known as The PACE Trial
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Monoclonal antibodies

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Hip, Jun 14, 2010.

  1. Hip

    Hip Senior Member

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    This looks like it could end up as a future therapy for chronic fatigue syndrome:

    Monoclonal antibodies: short-term therapy for the long-term treatment of chronic viral infections?

    From the 4th paragraph of the above link:

    ...under certain conditions, a very short course of treatment (a few days) with antiviral monoclonal antibodies can have an additional effect similar to that of a vaccine. After three weeks, and even though the injected monoclonal antibodies had disappeared, the researchers indeed detected a potent and long-lasting (more than a year) antiviral immune response...
  2. glenp

    glenp "and this too shall pass"

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    Vancouver Canada suburbs
    Very interesting!! I have often wondered what triggered good days that I used to have. I wonder if it could be antibodies?
    I hope they do something with this soon.

    glen
  3. randalbond

    randalbond

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    Yes, RItuximab (Mabthera) is one of them and is used in trials by Norway scientists to treat CFS. Actually, they must have finished their latest trial, but I don't see the results are out yet.
  4. redo

    redo Senior Member

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    Quote: "After three weeks, and even though the injected monoclonal antibodies had disappeared, the researchers indeed detected a potent and long-lasting (more than a year) antiviral immune response (...)"

    "In mice, a short and early course of therapeutic monoclonal antibodies targeting both the viruses and the cells infected by these viruses thus enables permanent recovery from a fatal chronic infection."

    Rituximab is a monoclonal antibody. And in a small trial it has given a strong temporary symptom relief lasting for over a month in 3/3 patients.

    Perhaps monoclonal antibodies work even better if the person have received or is receiving ARV at the same time. Just a though...
  5. mojoey

    mojoey Senior Member

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    One of the abstracts presented at the NIH conference talked about TSG101 as being a protein that was expressed on every cell infected with a retrovirus. It also discussed the possible therapy of using monoclonal antibodies that target TSG101.

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