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Mobilizing immune system against viruses: New way found

Discussion in 'Other Health News and Research' started by Ema, May 13, 2014.

  1. Ema

    Ema Senior Member

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    Mobilizing immune system against viruses: New way found
    Date:
    May 12, 2014

    Source:
    University of British Columbia

    University of British Columbia scientists have uncovered an intricate chain reaction in the body's immune system and have used the knowledge to develop a new treatment against harmful viruses.

    Viral pandemics, such as the coronavirus that caused the deadly SARS outbreak in 2002, have caused hundreds of deaths in Canada, yet effective anti-viral drugs are rare.

    A key element to this natural immune response is an antiviral protein in the blood called Interferon alpha. Like soldiers, Interferon alpha is quickly deployed by the body to fight viruses and removed just as quickly to restore equilibrium.

    As described in the current issue of the journal Nature Medicine, a team led by Overall from UBC's Department of Oral Biological and Medical Sciences and Bruce McManus from UBC's Department of Pathology and Laboratory Medicine has discovered that an enzyme called MMP12 serves double-duty in the deployment of the critical antiviral protein: it first enters the infected cell to activate Interferon alpha and then sends it outside the cell membrane to fight viruses. After the job of Interferon alpha is done, MMP12 dissolves the protein during the healing process.

    Overall has developed a new antiviral drug that blocks MMP12 from dissolving Interferon alpha outside the cell, giving the immune system an added boost by keeping levels of the protein high in the bloodstream. The drug cannot penetrate cell membranes, making it unable to interfere with the beneficial work inside the cell. The drug has been shown to effectively treat viral infections in mice models and holds promise as a new broad-spectrum antiviral treatment.

    "Because the drug isn't virus-strain specific and boosts the body's own immune response to fight infections, it could be effective for even emergent, unknown viruses and eliminate the lag time required to first identify and sequence the virus genetic material before we can treat it," says Overall.

    Story Source:

    The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.

    Journal Reference:

    1. David J Marchant, Caroline L Bellac, Theo J Moraes, Samuel J Wadsworth, Antoine Dufour, Georgina S Butler, Leanne M Bilawchuk, Reid G Hendry, A Gordon Robertson, Caroline T Cheung, Julie Ng, Lisa Ang, Zongshu Luo, Karl Heilbron, Michael J Norris, Wenming Duan, Taylor Bucyk, Andrei Karpov, Laurent Devel, Dimitris Georgiadis, Richard G Hegele, Honglin Luo, David J Granville, Vincent Dive, Bruce M McManus, Christopher M Overall. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.Nature Medicine, 2014; 20 (5): 493 DOI: 10.1038/nm.3508
     
  2. minkeygirl

    minkeygirl But I Look So Good.

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    @heapsreal, very interesting. is this similar to Immunovir or Cycloferon?
     
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    similar. cyclo and immunovir both stimulate the bodies natural interferon production. One way i have read how the russians treated viral infections was with interferon therapy and finished it with cycloferon as the interferon therapy would shut the own bodies production down and cyclo would help turn it back on??
     
  4. minkeygirl

    minkeygirl But I Look So Good.

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    So is this something maybe for the future? Will probably take forever to get this approved.
     

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