Hi all, after thinking a little bit about MLVs and CFS I wonder myself the following: 1) Many of us had a sudden onset 2) The low replication rates of MLVs as well as the course of HIV infection (retrovirus that slowly progresses to AIDS) give reason to the thought that MLV may not cause a sudden onset. I may be wrong of course. 3) For me it seems possible that like in HIV the MLVs render the immune system dysfunctional over time. The virus replicates itself over time and causes more and more damage that may lead to first symptoms but not a sudden onset. 4) At a certain point of time the infected people get struck down by Co-infections like EBV, HHV-6 etc. and interpret this as their beginning of the illness because this was the first time they had symptoms which were very nasty and didn't go away. 5) But what if the person got infected by XMRV well before that and XMRV smoothed the way for all kind of Infections? What if XMRV due to it's long replication cycles does not cause a sudden onset but attacks the immune system over time till people suddenly get struck down by another virus? I definetly do not exclude that MLVs cause damage by themselves and the WPI (if I remember correctly) said that it will soon show how they do this but could it be that MLVs rather need some time before we see first symptoms? If you have contradicting opinions pls feel free to comment. In my eyes treating MLVs would in this case still be the solution. MLVs cause damage and symptoms but not a sudden onset and as soon as the immune system works properly it will get rid of any other Co-infections.