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MLV caused leukaemia in kids!

Discussion in 'Media, Interviews, Blogs, Talks, Events about XMRV' started by bullybeef, Jan 24, 2012.

  1. bullybeef

    bullybeef Senior Member

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    North West, England, UK
    This is old news, but I believe it maybe highly relevant, and I couldn't find any previous mention of it.


    See: http://www.sciencedaily.com/releases/2003/06/030613074858.htm



    See: http://www.nytimes.com/2003/06/13/us/cancer-risk-exceeds-outlook-in-gene-therapy-studies-find.html


     
  2. SilverbladeTE

    SilverbladeTE Senior Member

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    Somewhere near Glasgow, Scotland
    But that cannot be! We have been told by the Almighty: the Men In White Coats, that cell lines and vaccines are safe!
    They would never lie! They would never make a mistake!


    :D


    CLICK ME!

    13580453.jpg
     
  3. Bob

    Bob

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    I didn't know that MoMuLV (an MLV) could infect human cells.
    Interestingly, two of the XMRV variants (VP29 and VP184) are said to be a recombination of XMRV + MoMuLV.
    Also, what's interesting is that this article says that the modified MoMuLV viruses caused leukemia in humans, suggesting that at least some unmodified MLVs might be able to infect humans, and cause leukemia.
    This ties in with Judy's cohort of patients, and Snyderman's disease and research.

    This paper says that MoMuLV envelope does not have a tropism for human cells, but I don't know what that's supposed to mean in practise, exactly.

    I'd like to know more about what unmodified MoMuLV does once it's infected a human. There must be some research on this.
    But just because it infects human cells, doesn't mean that isn't cleared out of the body by the immune system quickly after infection.
    So it would be helpful to know if unmodified MoMuLV causes leukemia in humans, the same as the modified virus.
    If anyone has any info on this, could they post please?
    I'm sure a google search will throw something up, so i'll look later.
     
  4. currer

    currer Senior Member

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    Bob, I think the paper you reference is only discussing the variants they found, and the tropism is defined by the envelope of the virus, which gets swapped around all the time in retroviruses.
    The reference below states that some MoMLVs can infect human cells depending on the envelope gene.

    http://www.stanford.edu/dept/EHS/prod/researchlab/bio/docs/Moloney_Murine_Leukemia_Virus.pdf

    This reference says that some variants on MoMLV can infect human cells.

    By modified are you talking about the gene therapy virus? Because nowadays they modify a retroviral vector so that it only undergoes one cycle of replication, just enough to insert the therapeutic gene. This is to prevent the MLV from inducing cancer in the new human host.

    (Im doing this from memory, I havent got any references handy!)
     
  5. Bob

    Bob

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    Ah, ok, thanks currer, that explains the 'tropism' comment then.

    Yes, that's right, I was.

    My thoughts about the modified virus were about whether the human immune system would respond differently to a virus which has been modified for gene therapy, compared to the natural wild virus.

    Well, that didn't seem to work then, did it!


    Thanku for helpful the info currer.
     

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