The Real ME: A Stock Photography Resource for the Media
We’ve all seen them in the news stories about ME/CFS: the guy in a suit at the office, yawning; the beautiful woman sitting at her desk with her immaculate make-up and elegantly coiffed hair, hand to her head and looking slightly pained.
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Discussion in 'General Treatment' started by SaraM, Feb 20, 2010.

  1. SaraM

    SaraM Senior Member

  2. glenp

    glenp "and this too shall pass"

    Vancouver Canada suburbs
    TY Sarah - it does look interesting. I wonder if it could also help us.
  3. George

    George Guest

    O.K. I'm just going to post it (grins)

    Introduction to Our Platform Technology

    Mitochondria, present in all cells, provide energy for life processes. It is now recognized that mitochondrial dysfunction plays a role in the pathogenesis of several degenerative disorders. Antioxidants are the body's defense against free radicals. Antioxidants block the effects of oxidation, a chemical reaction that combines single electrons with oxygen to generate free radicals, which can attack and destroy cells.

    Antipodean's proprietary targeted lipophilic cation technology prevents oxidative damage by concentrating antioxidants in mitochondria. MitoQ is targeted to mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation. Because of the large mitochondria membrane potential, the cations accumulate within cellular mitochondria up to 1,000 fold, compared to non-targeted antioxidants such as Coenzyme Q or its analogues. This accumulation enables the antioxidant moiety to block lipid peroxidation, and maintain the integrity of the mitochondria membrane by protecting it from oxidative damage.

    Antipodean's lead compound MitoQ (mitoquinone) is a mitochondria-targeted antioxidant that selectively blocks mitochondrial oxidative damage and prevents cell death. Mitochondrial dysfunction underlies a wide range of degenerative diseases, in which oxidative stress plays a key pathogenic role, including such diseases as NASH, Type 2 diabetes, ischemic heart disease, among others. Therefore, protecting mitochondria from oxidative damage is a promising and innovative therapeutic strategy.
    The lipophilic cation is accumulated 5- to 10- fold into the cytoplasm from the extracellular space by the plasma membrane potential and then further accumulated 100- to 500- fold into the mitochondrial matrix by the mitochondrial membrane potential.
    MitoQ is being evaluated as an oral treatment for liver inflammation that leads to fibrosis and is associated with metabolic dysfunction. The company is also investigating topical indications that involve mitochondrial dysfunction, including dermatologic applications and retinal degeneration.

  4. Chris

    Chris Senior Member

    Victoria, BC
    I am a bit late to this, but mitoQ is advertized as available from ProHealth--it is expensive--has anyone tried it yet? Chris
  5. I'm interested too if anyone has tried this yet?

  6. catly

    catly Senior Member

    outside of NYC
    I tried it for 2 months over this past winter. It didn't seem to do anything at all for me. I decided not to reorder due to the expense.
    Little Bluestem and Chris like this.
  7. EtherSpin

    EtherSpin Senior Member

    Melbourne , Australia
    anyone else had a crack? I see its about $2 AUD for a 5mg tablet at claimed 287 (interesting number!) efficiency gain over CoQ10 - I didn't realise it was available here and can see why Catly dropped it but one of my FB friends with CFS says it makes a tangible difference after a week or two of dosing.
    CoQ10 itself is one of those supps where the benefit has never been noticable to me but I've felt like I should be taking it so I buy a jar.. use it feel guilty,leave it for 6 months , hear another direct testimonial then go back on it again! is unsurprisingly one of the websites for it besides getting it through prohealth
  8. heapsreal

    heapsreal iherb 10% discount code OPA989,

    australia (brisbane)

    I have just recently started pqq which is suppose to help regenerate new mitochondria and is suppose to be good with q10.

    Been about 2 weeks and have 2 more weeks left. Hard to say if helping but nothing negative to report.
    Little Bluestem, minkeygirl and catly like this.
  9. lnester7

    lnester7 Seven

    @heapsreal I am finishing the bottle and to be honest I felt it crashes me instead of helping. Not ordering again?? Not suere if I should try the mito from Myhill instead. Have not reaserch enough yet.
    Little Bluestem and heapsreal like this.
  10. Chris

    Chris Senior Member

    Victoria, BC
    Tried it for 3 months--it seemed, maybe, to help a very little bit, but decided it was not worth the significant cost even if it did.
    Little Bluestem likes this.
  11. minkeygirl

    minkeygirl But I Look So Good.

    Left Coast
    I have some PQQ coming in 2 weeks. It was $14 so cheap enough to try for a month or 2.

    I bet with all the money we've all spent on supplements that didn't work we could have funded a lot of research.
    Little Bluestem and catly like this.

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