I would say around the 6 year mark I slowly started to improve. I should also mention that I started running a little at that time which I shouldn't have been doing because that was when PEM started- I didn't understand what it was back then. I would say around the 8-9 yr mark a Virologist rec'd I take Imunovir based my CD4, CD8 etc counts. I took them for 3 weeks and started feeling neuro/viral type symptoms and within one month I woke up one morning feeling very unwell, I went out to do some errands but within a couple of hours I could no longer walk and I was stuck on a downtown street. It happened that fast. Things just changed from there. Was it a viral reactivation? Was it an immune response? Who knows. The Virologist didn't know either. I prefer to leave my immune system alone from now on. What I really benefited from was magnesium and taurine injections. I took them on and off for years. You have to have an experienced ME/CFS doctor who monitors you before and during treatments with proper testing put in place. There are many who benefit from taking anit-virals and immunodulators so you can't rule it out.