http://www.sciencedirect.com/science/article/pii/S1567724915000215 Abstract Fibromyalgia is a chronic pain syndrome with unknown etiology. Recent studies have shown some evidence demonstrating that oxidative stress, mitochondrial dysfunction and inflammation may have a role in the pathophysiology of fibromyalgia. Despite several skin-related symptoms accompanied by small fiber neuropathy have been studied in FM, these mitochondrial changes have not been yet studied in this tissue. Skin biopsies from patients showed a significant mitochondrial dysfunction with reduced mitochondrial chain activities and bioenergetics levels and increased levels of oxidative stress. These data were related to increased levels of inflammation and correlated with pain, the principal symptom of FM. All these parameters have shown a role in peripheral nerve damage which has been observed in FM as a possible responsible to allodynia. Our findings may support the role of oxidative stress, mitochondrial dysfunction and inflammation as interdependent events in the pathophysiology of FM with a special role in the peripheral alterations. Full article requires research gate access, and can be found here: https://www.researchgate.net/public..._events_in_skin_of_patients_with_Fibromyalgia Thanks go to Co-cure alerts for this heads up. My comments - this is a tiny pilot study with what appears to be dramatic results. The graphic Fig. 1 B shows it all. The skin biopsies in fibro show skin that is more dead than alive. Its no wonder nerves are dying. This raises important questions. In ME or CFS or SEID or Fibro are there major differences in mitochondrial function in different tissues? Can we ever rely on blood tests again?